INT20929

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Context Info
Confidence 0.10
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Trim13) endoplasmic reticulum (Trim13) intracellular (Trim13)
ligase activity (Trim13) cytoplasm (Trim13) signal transducer activity (Trim13)
Anatomy Link Frequency
brain 2
Trim13 (Mus musculus)
Vas1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
Opioid 2 98.16 Very High Very High Very High
Delta opioid receptors 10 96.70 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether there are differences between delta opioid receptors in brain and mouse was deferens, the ability of a selective delta opioid compound, [D-Pen2,pCl-Phe4,D-Pen5]enkephalin (pCl-DPDPE), and [D-Ala2,(2R,3S)-delta E Phe4,Leu5]enkephalin methyl ester (CP-OMe), to inhibit [3H]pCl-DPDPE binding in both rat brain and mouse vas deferens were measured. pCl-DPDPE recognized brain and mouse vas deferens binding sites with equal affinity, however, CP-OMe showed 33 fold lower affinity in mouse vas deferens compared to brain.
Leu5 Binding (recognized) of vas in brain associated with enkephalin, delta opioid receptors and opioid
1) Confidence 0.10 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2160370 Disease Relevance 0 Pain Relevance 0.59
To investigate whether there are differences between delta opioid receptors in brain and mouse was deferens, the ability of a selective delta opioid compound, [D-Pen2,pCl-Phe4,D-Pen5]enkephalin (pCl-DPDPE), and [D-Ala2,(2R,3S)-delta E Phe4,Leu5]enkephalin methyl ester (CP-OMe), to inhibit [3H]pCl-DPDPE binding in both rat brain and mouse vas deferens were measured. pCl-DPDPE recognized brain and mouse vas deferens binding sites with equal affinity, however, CP-OMe showed 33 fold lower affinity in mouse vas deferens compared to brain.
Leu5 Binding (recognized) of vas in brain associated with enkephalin, delta opioid receptors and opioid
2) Confidence 0.10 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2160370 Disease Relevance 0 Pain Relevance 0.59

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