INT209299

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.72
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (St13) protein folding (St13) cytosol (St13)
protein complex (St13) cytoplasm (St13)
Anatomy Link Frequency
hip 4
knee 4
P48 2
dentate gyrus 2
cortex 2
St13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 96 100.00 Very High Very High Very High
Pyramidal cell 44 100.00 Very High Very High Very High
Lasting pain 1 83.92 Quite High
Somatosensory cortex 24 73.20 Quite High
Anterior cingulate 12 61.60 Quite High
Glutamate 8 55.68 Quite High
Nucleus accumbens 24 55.48 Quite High
Kinase C 8 46.40 Quite Low
Osteoarthritis 12 43.92 Quite Low
Neuronal excitability 4 40.88 Quite Low
Disease Link Frequency Relevance Heat
Frailty 133 100.00 Very High Very High Very High
Urological Neuroanatomy 24 100.00 Very High Very High Very High
Death 11 86.36 High High
Pain 4 83.92 Quite High
Osteoporosis 7 81.64 Quite High
Injury 3 77.44 Quite High
Hip Fractures 31 54.64 Quite High
Osteoporotic Fractures 2 48.16 Quite Low
Disease 7 25.00 Low Low
Arthritis 3 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteoporotic hip fracture is an established health problem in the West and is increasingly recognized as a growing problem in Asia as per the Asian Audit Report, 2009.1 With rising life expectancy throughout the globe, the number of elderly individuals is increasing in every geographical region, and it is estimated that the incidence of hip fracture will rise from 1.66 million in 1990 to 6.26 million by 2050.2
Positive_regulation (rise) of Gene_expression (fracture) of hip in hip associated with frailty
1) Confidence 0.36 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.97 Pain Relevance 0.08
Revision rates after hip resurfacing were increased especially in women.
Positive_regulation (increased) of Gene_expression (resurfacing) of hip in hip
2) Confidence 0.18 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2528048 Disease Relevance 0.06 Pain Relevance 0
The highest rates after hip replacement were seen in patients who had undergone hip resurfacing and the highest rates after knee replacement in patients who had a unicondylar prosthesis.
Positive_regulation (undergone) of Gene_expression (resurfacing) of hip in knee
3) Confidence 0.18 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2528048 Disease Relevance 0.16 Pain Relevance 0
The highest rates after hip replacement were seen in patients who had undergone hip resurfacing and the highest rates after knee replacement in patients who had a unicondylar prosthesis.
Positive_regulation (after) of Gene_expression (resurfacing) of hip in knee
4) Confidence 0.18 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2528048 Disease Relevance 0.16 Pain Relevance 0
Total protein expression of HIP TRPC4 and 5 proteins increased throughout development and peaked late in adulthood (6–9 weeks).
Positive_regulation (increased) of Gene_expression (expression) of HIP
5) Confidence 0.08 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1892805 Disease Relevance 0.17 Pain Relevance 0.26
This work in cell culture systems is consistent with our finding of increased developmental expression of TRPC5 in HIP, PFC, SUB, and entorhinal cortex.
Positive_regulation (increased) of Gene_expression (expression) of HIP in cortex associated with hippocampus
6) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.27
HIP TRPC5 protein is present at low levels from embryonic day 18 (E18) E18 to P20 and increase robustly from P20 to P48 (Figure 8B).
Positive_regulation (increase) of Gene_expression (present) of HIP in P48 associated with hippocampus
7) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.14
In adults, TRPC4 expression was high throughout the frontal cortex, lateral septum (LS), pyramidal cell layer of the hippocampus (HIP), dentate gyrus (DG), and ventral subiculum (vSUB).
Positive_regulation (high) of Gene_expression (expression) of HIP in dentate gyrus associated with pyramidal cell, urological neuroanatomy and hippocampus
8) Confidence 0.06 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1892805 Disease Relevance 0.19 Pain Relevance 0.37

General Comments

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