INT2093

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Context Info
Confidence 0.78
First Reported 1978
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 50
Total Number 50
Disease Relevance 32.32
Pain Relevance 7.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GAST) extracellular region (GAST)
Anatomy Link Frequency
plasma 2
G cells 2
nerve 2
stomach 2
common bile duct 1
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 46 100.00 Very High Very High Very High
Somatostatin 27 100.00 Very High Very High Very High
Calcitonin gene-related peptide 17 100.00 Very High Very High Very High
Serotonin 11 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Dopamine 6 100.00 Very High Very High Very High
agonist 23 99.90 Very High Very High Very High
antagonist 27 99.44 Very High Very High Very High
Neuropeptide 6 98.92 Very High Very High Very High
cINOD 12 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 184 100.00 Very High Very High Very High
Cancer 230 99.98 Very High Very High Very High
Hyperglycemia 2 99.92 Very High Very High Very High
Colon Cancer 19 99.64 Very High Very High Very High
Pharyngitis 100 99.58 Very High Very High Very High
Carcinoid 49 99.54 Very High Very High Very High
Adenocarcinoma 25 99.44 Very High Very High Very High
Rheumatic Fever 286 99.16 Very High Very High Very High
Hepatotoxicity 1 99.16 Very High Very High Very High
Peripheral Primitive Neuroectodermal Tumors 2 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Except for the normal serum gastrin levels, this constellation was suggestive of a gastrinoma, so that further investigations were initiated.
Gene_expression (levels) of gastrin associated with gastrinoma
1) Confidence 0.78 Published 2010 Journal Med. Klin. (Munich) Section Abstract Doc Link 20455041 Disease Relevance 0.81 Pain Relevance 0.16
Immunoperoxidase staining for gastrin-producing G cells, somatostatin-producing D cells and serotonin-producing EC cells was carried out on fundic, antral and duodenal biopsies, and was quantified using a Zeiss MOP Videoplan using the peroxidase-antiperoxidase technique of Sternberger.
Gene_expression (producing) of gastrin in D cells associated with somatostatin and serotonin
2) Confidence 0.75 Published 1996 Journal Can. J. Gastroenterol. Section Abstract Doc Link 9193776 Disease Relevance 0.48 Pain Relevance 0.31
Gas was detected in the gallbladder on plain abdominal X-rays and CT scans of the abdomen, and a small amount of gas was also observed in the common bile duct.
Gene_expression (detected) of Gas in common bile duct associated with bile
3) Confidence 0.75 Published 1996 Journal Tokai J. Exp. Clin. Med. Section Abstract Doc Link 9239802 Disease Relevance 0.82 Pain Relevance 0.25
Gas production as a part of disk degeneration can occur, but it rarely causes clinical nerve compression syndromes.
Gene_expression (production) of Gas in nerve associated with nerve compression syndromes
4) Confidence 0.75 Published 2000 Journal J Spinal Disord Section Abstract Doc Link 11132986 Disease Relevance 0.40 Pain Relevance 0.27
The aim of this study was to investigate the ultrastructural appearance of pancreatic adenocarcinoma combined with glucagon and gastrin/cholecystokinin (CCK) expression.
Gene_expression (expression) of gastrin associated with adenocarcinoma and cholecystokinin
5) Confidence 0.75 Published 2007 Journal Ultrastruct Pathol Section Abstract Doc Link 17786831 Disease Relevance 0.57 Pain Relevance 0.27
The patient was a 36-year-old female who had a past history of type 1 multiple endocrine adenomatosis, namely, adenomatosis of the parathyroid gland, insulin and gastrin-producing adenomatosis of the pancreas, and prolactin-producing pituitary adenoma.
Gene_expression (producing) of gastrin in pancreas associated with multiple endocrine neoplasia type 1 and pituitary cancer
6) Confidence 0.75 Published 1985 Journal Hinyokika Kiyo Section Abstract Doc Link 2862784 Disease Relevance 1.46 Pain Relevance 0.09
Gas production as a part of disk degeneration can occur but rarely causes nerve compression syndromes.
Gene_expression (production) of Gas in nerve associated with nerve compression syndromes
7) Confidence 0.75 Published 2005 Journal Eur J Radiol Section Abstract Doc Link 16168257 Disease Relevance 0.33 Pain Relevance 0.25
Increased and ectopic gastrin/CCK expression was correlated with pancreatic adenocarcinomas exhibiting poor histological grade and neoplastic endocrine cells, providing a potential marker for pancreatic adenocarcinomas with aggressive behavior.
Gene_expression (expression) of gastrin in endocrine cells associated with adenocarcinoma, aggression and cholecystokinin
8) Confidence 0.75 Published 2007 Journal Ultrastruct Pathol Section Abstract Doc Link 17786831 Disease Relevance 1.22 Pain Relevance 0.24
Shortly thereafter, Edkins reported results of studies that supported the presence of an acid regulatory hormone, gastrin, in the antrum of the stomach.
Gene_expression (presence) of gastrin in stomach
9) Confidence 0.67 Published 1990 Journal Surg Gynecol Obstet Section Abstract Doc Link 2152987 Disease Relevance 0.61 Pain Relevance 0.25
The mean serum gastrin concentrations in both groups were similar (21.6±9.8 vs. 20.2±11.0 pg/mL).
Gene_expression (concentrations) of gastrin
10) Confidence 0.66 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2808598 Disease Relevance 0.30 Pain Relevance 0.04
Gas formation was present in 5 of the 12 patients recorded, and 4 of them died during hospitalization.
Gene_expression (present) of Gas
11) Confidence 0.65 Published 2001 Journal J Microbiol Immunol Infect Section Abstract Doc Link 11605812 Disease Relevance 1.19 Pain Relevance 0.09
Complete removal of the gastrinoma was suggested by comparative gastric analyses, by serum gastrin levels of 93, 180, and 167 pg/ml, and by the clinical course.
Gene_expression (levels) of gastrin associated with gastrinoma
12) Confidence 0.60 Published 1984 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6475895 Disease Relevance 0.85 Pain Relevance 0.08
Reporter gene assays were performed with the gastrin-stimulated human colorectal cancer cell-line Colo-320, which was stable transfected with the human cholecystokinin-B/gastrin receptor cDNA and COX-2-promoter-luciferase constructs containing different segments of the 5'-region of the COX-2 gene or with mutated promoter constructs.
Gene_expression (transfected) of gastrin associated with colon cancer and cholecystokinin
13) Confidence 0.60 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17604853 Disease Relevance 0.50 Pain Relevance 0.13
Expression of the cholecystokinin (CCK), gastrin and enkephalin A genes were studied by Northern blot analysis and a library of sequence-specific radioimmunoassays in human cell lines.
Gene_expression (Expression) of gastrin associated with enkephalin and cholecystokinin
14) Confidence 0.60 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 1977617 Disease Relevance 0.46 Pain Relevance 0.44
METHODS: Platelet lumiaggregation, skin bleeding time, plasma levels of aspirin and salicylic acid, and serum gastrin levels were determined in 14 healthy men before and after the ingestion of 125 mg aspirin with or without previous treatment with 20 mg/day of omeprazole for 4 days before testing.
Gene_expression (levels) of gastrin in plasma
15) Confidence 0.59 Published 2000 Journal Scand. J. Gastroenterol. Section Body Doc Link 10766315 Disease Relevance 0 Pain Relevance 0
The main aim of the study was to assess the safety and efficacy of the production of antigastrin antibodies.
Gene_expression (production) of gastrin
16) Confidence 0.58 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 11156225 Disease Relevance 0.73 Pain Relevance 0
Immunocytochemical and morphometric studies of gastrin-, somatostatin- and serotonin-producing cells in the stomach and duodenum of patients with acid peptic disorders.
Gene_expression (producing) of gastrin in stomach associated with somatostatin and serotonin
17) Confidence 0.58 Published 1996 Journal Can. J. Gastroenterol. Section Title Doc Link 9193776 Disease Relevance 0.54 Pain Relevance 0.32
Incubation with the antibodies against somatostatin, enkephalin, bombesin, peptide histidine isoleucine amide (PHI), cholecystokinin (CCK)/gastrin and dopamine-beta-hydroxylase (DBH) was negative for the fungiform papillae.
Neg (negative) Gene_expression (negative) of gastrin in papillae associated with dopamine, somatostatin, enkephalin and cholecystokinin
18) Confidence 0.58 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8577944 Disease Relevance 0.08 Pain Relevance 0.41
Alpha-galactosidase reduced gas production following a meal rich in fermentable carbohydrates and may be helpful in patients with gas-related symptoms.
Gene_expression (production) of gas
19) Confidence 0.58 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17151807 Disease Relevance 0.54 Pain Relevance 0.15
Immunohistochemical investigation of gastrin-producing cells (G cells).
Gene_expression (producing) of gastrin in G cells
20) Confidence 0.58 Published 1978 Journal Scand. J. Gastroenterol. Section Title Doc Link 345416 Disease Relevance 0.85 Pain Relevance 0.09

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