INT209307

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.59
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpc4) protein complex (Trpc4) transmembrane transport (Trpc4)
cytoplasm (Trpc4)
Anatomy Link Frequency
neuronal 2
hilus 2
Trpc4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 120 97.84 Very High Very High Very High
Pyramidal cell 55 96.72 Very High Very High Very High
Action potential 15 95.12 Very High Very High Very High
agonist 10 93.60 High High
Glutamate receptor 5 92.96 High High
Somatosensory cortex 30 91.04 High High
Nucleus accumbens 30 88.32 High High
Anterior cingulate 15 87.92 High High
amygdala 15 80.08 Quite High
tetrodotoxin 5 63.12 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 30 92.36 High High
Hypersensitivity 10 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both species TRPC4 expression is very high in CA1 while moderate expression in CA2 and DG, and little expression in CA3 and hilus is observed.
Positive_regulation (high) of Gene_expression (expression) of TRPC4 in hilus
1) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.31 Pain Relevance 0.42
Developmental expression of TRPC4 and 5 proteins
Positive_regulation (proteins) of Gene_expression (expression) of TRPC4
2) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.12
Total protein expression of HIP TRPC4 and 5 proteins increased throughout development and peaked late in adulthood (6–9 weeks).
Positive_regulation (increased) of Gene_expression (expression) of TRPC4
3) Confidence 0.42 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1892805 Disease Relevance 0.17 Pain Relevance 0.26
This dADP correlated with the presence of TRPC4 and 5 expression.
Positive_regulation (presence) of Gene_expression (expression) of TRPC4
4) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.34
As with TRPC4, no significant TRPC5 expression was detected in layer 1 of the PFC where there are few neuronal cell bodies.
Positive_regulation (detected) of Gene_expression (expression) of TRPC4 in neuronal
5) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.11 Pain Relevance 0.38

General Comments

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