INT209319

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (VKORC1) endoplasmic reticulum (VKORC1)
Anatomy Link Frequency
liver 1
VKORC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 4 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
peptic ulcer disease 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 60 97.56 Very High Very High Very High
Injury 57 96.32 Very High Very High Very High
Burns 64 96.04 Very High Very High Very High
Cirrhosis 7 94.76 High High
Hemostatic Disorders 1 93.48 High High
Congenital Anomalies 2 92.24 High High
Thrombosis 1 90.80 High High
Coagulation Disorder 2 88.20 High High
Thrombophilia 1 85.44 High High
Sepsis 5 69.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The liver produces most of the factors involved in coagulation and fibrinolysis that helps maintain the balance between thrombin deposition and removal.38 Patients with cirrhosis frequently experience hemostatic disorders caused by abnormalities of platelet number and/or function, increased fibrinolysis, and deficient synthesis of clotting factors.38 Clotting factor deficiencies develop with the loss of functioning liver paranchymal cells, with early deficits in the Vitamin KĀ–dependent factors (II, VII, IX, X, protein S, and protein C).38 The loss of factor VII significantly interferes with the function of the extrinsic coagulation cascade.38 Hemorrhagic complication is a major concern in patients with cirrhosis undergoing surgical interventions39 and must be considered when preparing a patient with burn injury with preexisting liver disease for surgery.
Gene_expression (produces) of factors in liver associated with liver disease, coagulation disorder, cirrhosis, burns, congenital anomalies, injury and hemostatic disorders
1) Confidence 0.01 Published 2007 Journal J Burns Wounds Section Body Doc Link PMC1892842 Disease Relevance 1.95 Pain Relevance 0

General Comments

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