INT209323

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.22
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 86 91.28 High High
COX-2 inhibitor 113 83.24 Quite High
aspirin 37 80.96 Quite High
Inflammation 35 50.00 Quite Low
COX2 2 50.00 Quite Low
Paracetamol 15 22.68 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Analgesic 8 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 61 99.92 Very High Very High Very High
Metastasis 7 96.52 Very High Very High Very High
Malignant Neoplastic Disease 7 93.52 High High
Apoptosis 156 93.00 High High
Lymphatic System Cancer 4 90.48 High High
Cancer 244 87.20 High High
Intestinal Cancer 3 85.44 High High
Toxicity 11 77.28 Quite High
Ovarian Cancer 1 77.24 Quite High
Pancreatic Cancer 1 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has recently been discovered that up-regulation of COX-2 and correlative production of prostaglandin E2 (PGE2) effectively and specifically induces the promoter II region of the cytochrome P-450 gene (CYP-19) which is transcribed and translated into aromatase, the chief enzyme in the biosynthesis of estrogen 47, 48.
Positive_regulation (induces) of Transcription (transcribed) of CYP-19
1) Confidence 0.32 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1893117 Disease Relevance 0.81 Pain Relevance 0
It has recently been discovered that up-regulation of COX-2 and correlative production of prostaglandin E2 (PGE2) effectively and specifically induces the promoter II region of the cytochrome P-450 gene (CYP-19) which is transcribed and translated into aromatase, the chief enzyme in the biosynthesis of estrogen 47, 48.
Positive_regulation (induces) of Transcription (transcribed) of aromatase
2) Confidence 0.32 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1893117 Disease Relevance 0.82 Pain Relevance 0
Of particular relevance to breast cancer, PGs can increase estrogen biosynthesis via upregulation of aromatase transcription (discussed below).
Positive_regulation (upregulation) of Transcription (transcription) of aromatase associated with breast cancer
3) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.09 Pain Relevance 0
Research conducted across several vertebrate classes has shown that atrazine exposure can inhibit androgen production and increase estrogens by increasing aromatase transcription (Crain et al. 1997; Fan et al. 2007; Sanderson et al. 2002).
Positive_regulation (increasing) of Transcription (transcription) of aromatase
4) Confidence 0.06 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592273 Disease Relevance 0.29 Pain Relevance 0
Moreover, prostaglandins were able to increase cell proliferation of hormonal-dependent breast cancer by increasing transcription of CYP19 aromatase implicated in estrogen biosynthesis [87].
Positive_regulation (increasing) of Transcription (transcription) of CYP19 aromatase associated with breast cancer
5) Confidence 0.02 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.21 Pain Relevance 0.33

General Comments

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