INT209417

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 6.69
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ERG) signal transduction (ERG) nucleus (ERG)
DNA binding (ERG) cytoplasm (ERG) signal transducer activity (ERG)
Anatomy Link Frequency
eye 5
retina 3
eye cup 1
amacrine cells 1
photoreceptor cell 1
ERG (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 25 94.88 High High
anesthesia 38 94.04 High High
Inflammation 102 90.92 High High
qutenza 8 88.08 High High
cva 5 82.56 Quite High
dexamethasone 5 66.64 Quite High
medulla 20 58.48 Quite High
tetrodotoxin 4 57.92 Quite High
Codeine 64 55.36 Quite High
antagonist 18 37.60 Quite Low
Disease Link Frequency Relevance Heat
Injury 83 99.32 Very High Very High Very High
Cough 204 98.28 Very High Very High Very High
Gliosis 12 97.80 Very High Very High Very High
Leber Congenital Amaurosis /

Leber Congenital Amaurosis

129 94.16 High High
Ocular Hypertension 211 92.80 High High
Blister 10 91.80 High High
INFLAMMATION 102 91.64 High High
Mydriatic 10 89.04 High High
Myopia 22 86.32 High High
Uveitis 12 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ERt/ERg are likely produced and controlled by different mechanisms than the expulsions in cough [5,7,22,35].
Gene_expression (produced) of ERg associated with cough
1) Confidence 0.20 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.97 Pain Relevance 0
During ERt (Fig. 1, 2 and 3) or ERg [4,5], only the adductor activation presents as a biphasic response; the PCA is activated in a single short burst.
Gene_expression (presents) of ERg in adductor
2) Confidence 0.19 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.72 Pain Relevance 0.15
Glottal stimuli applied in 31 animals produced ERg 99.5% of the time (426 out of 428 stimulations, 279 during expiration and 149 during inspiration).
Gene_expression (produced) of ERg
3) Confidence 0.17 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0 Pain Relevance 0.06
This is in line with vigorous expression of ERg when stimuli were delivered during expiration, particularly at the beginning of an expiratory period [20,21].
Gene_expression (expression) of ERg
4) Confidence 0.17 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0 Pain Relevance 0
At high concentrations (0.5mM), bumetanide is reported to inhibit the b-wave of the electroretinogram (ERG) in fish eye cup [39], but the ERG appears little affected at concentrations of bumetanide as used here.
Neg (little) Gene_expression (affected) of ERG in eye cup
5) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.20 Pain Relevance 0.06
RPE65-mutant human retinas (five ERG recordings available) were either nonresponsive to all stimuli (n = 3) or only responded at maximal stimulation (n = 2).
Gene_expression (recordings) of ERG in retinas
6) Confidence 0.11 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1896221 Disease Relevance 0.13 Pain Relevance 0.03
The anesthetic regimen is comparable to that used for ERG acquisition and preserves optokinetic responses [18].
Gene_expression (acquisition) of ERG
7) Confidence 0.11 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1896221 Disease Relevance 0 Pain Relevance 0.23
The ERG responses were recorded by stimulating the retina with light intensities ranging between10?
Gene_expression (responses) of ERG in retina
8) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0 Pain Relevance 0
Student's t test was performed for paired series of ERG and cell counts.
Gene_expression (series) of ERG
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957406 Disease Relevance 0 Pain Relevance 0
In agreement with this prediction we found that these stimuli evoked equivalent ERG responses over this wide wavelength range (Fig. 2F).
Gene_expression (responses) of ERG
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0 Pain Relevance 0
3 scotopic cd/m2, around the threshold for a measurable ERG response in these mice), and its magnitude increased, and latency decreased as a function of stimulus irradiance.
Gene_expression (response) of ERG
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0 Pain Relevance 0
The presence of a measurable ERG in TKO mice raises the possibility that these animals may retain a wide array of light responses.
Gene_expression (presence) of ERG
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0 Pain Relevance 0
Scotopic ERG responses were recorded by stimulating the retina with light intensities between 10?
Gene_expression (responses) of ERG in retina
13) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0 Pain Relevance 0
Animals were dark-adapted for 8 h before ERG recordings, and they were manipulated under dim red light (?
Gene_expression (recordings) of ERG
14) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.62 Pain Relevance 0.21
This indicates why ERG reductions as a consequence of intracameral inoculation proved significantly less pronounced than those for mice receiving a lens puncture wound
Gene_expression (reductions) of ERG in lens associated with injury
15) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.43 Pain Relevance 0.11
This also correlated with neuroretinal trauma evidenced by a sustained loss in ERG function, increased GFAP levels indicative of active Muller as well as astrocyte cell gliosis, and significant photoreceptor cell degeneration.
Gene_expression (levels) of ERG in photoreceptor cell associated with injury and gliosis
16) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 1.10 Pain Relevance 0.15
The rd12 eye, which received a subretinal injection four weeks after an intravitreal injection in the contralateral eye of the same mouse (Figure 3C), showed robust, dark-adapted ERG restoration five months after the subretinal injection.
Gene_expression (restoration) of ERG in eye
17) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633462 Disease Relevance 0 Pain Relevance 0
Twenty mice met this standard in the study, which included three rd12 mice that received only a single subretinal injection for ERG examination, three rd12 mice that received an intravitreal injection followed by a subretinal injection in the partner eyes for ERG examination, six rd12 mice that received an intravitreal injection followed by subretinal injection in partner eyes for immunostaining, and eight C57BL/6J mice that received intravitreal injection followed by subretinal injection in partner eyes for retinal whole-mount and sectioning examinations.
Spec (examination) Gene_expression (examination) of ERG in eyes
18) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633462 Disease Relevance 0.49 Pain Relevance 0.07
Twenty mice met this standard in the study, which included three rd12 mice that received only a single subretinal injection for ERG examination, three rd12 mice that received an intravitreal injection followed by a subretinal injection in the partner eyes for ERG examination, six rd12 mice that received an intravitreal injection followed by subretinal injection in partner eyes for immunostaining, and eight C57BL/6J mice that received intravitreal injection followed by subretinal injection in partner eyes for retinal whole-mount and sectioning examinations.
Spec (examination) Gene_expression (examination) of ERG in eyes
19) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633462 Disease Relevance 0.51 Pain Relevance 0.10
In parallel experiments, we found that rd12 eyes showed similar rod-related ERG restoration following either an initial subretinal injection of scAAV2-smCBA-RPE65 or a second subretinal injection when the other eye had received an intravitreal injection of the same vector four weeks before.
Gene_expression (restoration) of ERG in eye
20) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633462 Disease Relevance 0.19 Pain Relevance 0

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