INT209419

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.03
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GPSM2) nucleolus (GPSM2) nucleus (GPSM2)
cytoplasm (GPSM2)
Anatomy Link Frequency
brains 1
Optic nerve 1
GPSM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 9 87.80 High High
anesthesia 13 83.80 Quite High
Central nervous system 69 68.32 Quite High
Buprenorphine 3 60.00 Quite High
analgesia 3 58.36 Quite High
isoflurane 3 49.20 Quite Low
ketamine 9 45.92 Quite Low
glial activation 6 41.96 Quite Low
tetrodotoxin 16 30.56 Quite Low
Action potential 6 30.28 Quite Low
Disease Link Frequency Relevance Heat
Leber Congenital Amaurosis /

Leber Congenital Amaurosis

62 99.82 Very High Very High Very High
Ocular Hypertension 213 99.44 Very High Very High Very High
Optic Nerve Injuries 105 98.52 Very High Very High Very High
Frailty 15 96.72 Very High Very High Very High
Ganglion Cysts 27 95.96 Very High Very High Very High
Injury 19 90.40 High High
Glaucoma 27 88.36 High High
Neurodegenerative Disease 9 52.48 Quite High
Blindness 8 50.00 Quite Low
Photophobia 1 15.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LGN was blocked in the coronal plane, frozen on dry ice and stored at ?
Regulation (frozen) of LGN
1) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.07 Pain Relevance 0.20
Interestingly, however, in our study there was no measurable microglial response in the LGN or V1 of the OHT brains even after durations as long as 58 days post elevated IOP.
Neg (no) Regulation (response) of LGN in brains associated with ocular hypertension
2) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 1.60 Pain Relevance 0.06
MAC-1 immunoreactivity was at background levels in the LGN (Figure 3C and Figure 5A) and V1 (Figure 4C) of the animals with unilateral OHT.
Regulation (immunoreactivity) of LGN associated with ocular hypertension
3) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.78 Pain Relevance 0.03
Optic nerve diameter was no different from normal in patients with RPE65-LCA, and no alteration of the LGN was found.
Neg (no) Regulation (alteration) of LGN in Optic nerve
4) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1896221 Disease Relevance 0.17 Pain Relevance 0.04
It is possible that MHCI genes are expressed prenatally in the marmoset LGN, as the segregation of LGN layers in primates occurs in utero [39,40].
Regulation (segregation) of LGN
5) Confidence 0.02 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0

General Comments

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