INT209423

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.40
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) lysosome (Ctsk)
cytoplasm (Ctsk)
Anatomy Link Frequency
lacuna 2
macrophages 1
bone marrow 1
Ctsk (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 126 96.00 Very High Very High Very High
Inflammation 58 93.88 High High
Tendonitis 1 85.52 High High
rheumatoid arthritis 80 84.84 Quite High
cytokine 55 84.24 Quite High
antagonist 5 42.96 Quite Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 46 97.84 Very High Very High Very High
Arthritis 135 96.00 Very High Very High Very High
Death 6 94.96 High High
INFLAMMATION 59 93.88 High High
Tendinopathy 1 85.52 High High
Rheumatoid Arthritis 80 84.84 Quite High
Synovitis 8 76.96 Quite High
Hypercalcemia 19 75.76 Quite High
Disease 28 56.64 Quite High
Pressure And Volume Under Development 11 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to Väänänen et al [32], a high level of CatK expression secreted by osteoclasts in the lacuna is an indicator of the resorption process.
Negative_regulation (level) of Gene_expression (expression) of CatK in lacuna
1) Confidence 0.41 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.46 Pain Relevance 0.09
Both Cathepsin K and CTR were expressed at similar levels in bones from WT or K?
Negative_regulation (levels) of Gene_expression (expressed) of Cathepsin K
2) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.07 Pain Relevance 0
Mouse spleen cells and bone marrow macrophages express IL-4 and IL-13 receptors, and the addition of these factors decreased RANKL-stimulated tartrate-resistant acid phosphatase-positive multi-nucleated cell formation and cathepsin K message in spleno-cytes and bnone marrow macrophages [80].
Negative_regulation (decreased) of in macrophages Gene_expression (message) of cathepsin K in bone marrow
3) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.59 Pain Relevance 0.26
IL-17, IL-12, cathepsin K and osteoprotegrin ligand mRNA levels were also reduced [86, 87].
Negative_regulation (reduced) of Gene_expression (levels) of cathepsin K
4) Confidence 0.03 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.29 Pain Relevance 0.62

General Comments

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