INT209424

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.03
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tyrobp)
Anatomy Link Frequency
lymphocyte 1
Osteoclast 1
Tyrobp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 97.60 Very High Very High Very High
rheumatoid arthritis 12 84.40 Quite High
withdrawal 12 83.28 Quite High
Arthritis 37 71.40 Quite High
cytokine 23 56.36 Quite High
Pain 2 49.04 Quite Low
agonist 20 10.00 Low Low
imagery 7 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Cancer 2 98.12 Very High Very High Very High
INFLAMMATION 30 97.60 Very High Very High Very High
Osteopetrosis 25 92.40 High High
Targeted Disruption 4 90.80 High High
Hypercalcemia 47 90.76 High High
Leukoencephalopathies 1 87.20 High High
Rheumatoid Arthritis 12 84.40 Quite High
Disease 34 83.44 Quite High
Pressure And Volume Under Development 9 78.20 Quite High
Arthritis 53 71.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of still unknown ligands to DAP12- and FcR?
DAP12 Binding (binding) of
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.26 Pain Relevance 0
In addition, recent data have implicated co-stimulatory signals through DAP12 and FcR?
DAP12 Binding (signals) of
2) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.32 Pain Relevance 0.03
Osteoclast differentiation from hematopoietic progenitors and their activation depend on M-CSF and RANKL, but also requires co-stimulatory signals acting through receptors associated with DAP12 and FcR?
DAP12 Binding (associated) of in Osteoclast
3) Confidence 0.32 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1899087 Disease Relevance 0.09 Pain Relevance 0.04
In the physiopathological context of gonadal failure, DAP12 impairment and lymphocyte depletion do not act synergistically since bone mass reduction after ovariectomy is the same when either one or both of these factors are disturbed (Data S2).
DAP12 Neg (impairment) Binding (impairment) of in lymphocyte
4) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.17 Pain Relevance 0.04
Previous studies have shown that the pairing partner of MDL-1 receptor—DAP12 has important roles in bone metabolism.
DAP12 Binding (partner) of
5) Confidence 0.29 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.18 Pain Relevance 0.22

General Comments

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