INT209428

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tyrobp)
Anatomy Link Frequency
myeloid cell 1
osteoclasts 1
Tyrobp (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 40 99.40 Very High Very High Very High
Inflammatory response 4 90.64 High High
cytokine 18 88.40 High High
Arthritis 74 78.40 Quite High
Inflammation 72 62.16 Quite High
rheumatoid arthritis 17 45.52 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 24 100.00 Very High Very High Very High
INFLAMMATION 60 90.24 High High
Arthritis 106 86.08 High High
Pressure And Volume Under Development 18 80.28 Quite High
Injury 4 54.08 Quite High
Disease 47 52.72 Quite High
Arthropathy 10 46.88 Quite Low
Rheumatoid Arthritis 17 45.52 Quite Low
Osteoporosis 7 29.84 Quite Low
Osteopetrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mature lymphocytes do not stimulate bone resorption activity of Dap12-deficient osteoclasts
Neg (not) Positive_regulation (stimulate) of Dap12 in osteoclasts associated with hypercalcemia
1) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.10 Pain Relevance 0
Cross-linking cell surface MDL-1 receptors induces DAP12-ITAM–dependent calcium mobilization (Bakker et al., 1999) and activation of the Syk and phospholipase C?
Positive_regulation (induces) of DAP12
2) Confidence 0.39 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.26 Pain Relevance 0.10
Also, myeloid cell–specific genes including CD11b, RANK, and DAP12 are reduced in the MDL-1–Ig fusion group and elevated in anti–MDL-1 agonist group.
Positive_regulation (elevated) of DAP12 in myeloid cell associated with agonist
3) Confidence 0.39 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.43 Pain Relevance 0.30

General Comments

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