INT209435

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.55
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tyrobp)
Anatomy Link Frequency
long bones 1
Tyrobp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 99.28 Very High Very High Very High
rheumatoid arthritis 9 94.24 High High
Arthritis 37 88.76 High High
agonist 20 85.76 High High
cytokine 11 42.96 Quite Low
withdrawal 3 8.36 Low Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 25 99.32 Very High Very High Very High
INFLAMMATION 30 99.28 Very High Very High Very High
Bone Cancer 2 97.96 Very High Very High Very High
Rheumatoid Arthritis 9 94.24 High High
Arthritis 53 88.76 High High
Osteopetrosis 7 81.04 Quite High
Hypercalcemia 17 76.40 Quite High
Arthropathy 5 75.44 Quite High
Osteoporosis 5 53.08 Quite High
Endometriosis (extended) 1 9.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, TREM2 or DAP12 deficiencies are responsible for Nasu-Hakola disease, a rare human disease, characterized at the bone level, by osteoporotic lesions at the extremities of long bones [12], [13].
Regulation (responsible) of DAP12 in long bones associated with disease
1) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.38 Pain Relevance 0
Further clinical studies are needed to confirm a pathogenic role for MDL-1 in human skeletal disorders and to determine whether this DAP12-paring receptor is a therapeutic target for treatment of inflammatory and/or degenerative bone disorders.


Spec (whether) Regulation (target) of DAP12 associated with inflammation and bone cancer
2) Confidence 0.21 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.17 Pain Relevance 0.37

General Comments

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