INT209439

Context Info Confidence 0.26 First Reported 2007 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 3.25 Pain Relevance 2.00

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr) cytoplasm (Gsr)

Anatomy Link Frequency macrophages 1 monocytes 1 dendritic cells 1 neutrophil 1 mononuclear phagocytes 1 Gsr (Mus musculus)

Pain Link Frequency Relevance Heat lidocaine 204 98.58 Inflammation 299 93.24 fibrosis 2 78.20 chemokine 61 66.76 Arthritis 112 59.68 withdrawal 6 56.88 aspirin 8 53.60 ischemia 8 50.00 agonist 26 47.24 COX-2 inhibitor 2 45.12

Disease Link Frequency Relevance Heat Adhesions 15 97.76 Apoptosis 40 97.56 Mycobacterial Infection 147 95.20 INFLAMMATION 321 93.24 Death 3 91.48 Injury 22 90.96 Hypercalcemia 20 82.04 Infection 113 79.60 Fibrosis 2 78.20 Hyperplasia 2 76.56

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The numbers of CD11b+ monocytes, and Gr1+ granulocytes were not modified.

Localization (granulocytes) of Gr1 in monocytes

1) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.14 Pain Relevance 0.03

In contrast, in spleen, the numbers of B220+ B lymphocytes, CD11b+ monocytes, CD11c+ dendritic cells and Gr1+ granulocytes were similar in both K?

Localization (granulocytes) of Gr1 in dendritic cells

2) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.13 Pain Relevance 0.03

To investigate the possible effects of MC3R gene ablation on adhesion molecule expression on circulating leukocytes during I/R, we investigated the expression of CD11b and CD62L on granulocytes (GR-1hi) and mononuclear phagocytes (F4/80+).

Localization (granulocytes) of GR-1hi in mononuclear phagocytes associated with adhesions

3) Confidence 0.22 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.27 Pain Relevance 0.03

For this reason, we experimentally determined the timing of accumulation of Gr1+ neutrophilic population (CD11b+ Gr1+) (Figure 5a) [68] and Gr1+ monocytic population (CD11b?

Localization (population) of Gr1

4) Confidence 0.17 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.97 Pain Relevance 0.17

Peritoneal cells collected from mice receiving lidocaine (at both 0.08% and 0.008%) together with zymosan showed significantly decreased annexin-V+Gr-1+ cells by 50% and 64%, respectively, indicating reduced PMN apoptosis (Fig. 3A).

Localization (decreased) of Gr-1 associated with apoptosis and lidocaine

5) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.49 Pain Relevance 0.82

Cells with positive staining of both F4/80 and Gr-1 were then monitored by FACS analysis.

Localization (staining) of Gr-1 in F4/80

6) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.33 Pain Relevance 0.64

g/ml primary rat mAbs directed against mouse Mac-1 (macrophages and neutrophil granulocytes; Medac, Wedel, Germany) or Gr-1 (neutrophil granulocytes; BD Biosciences, Heidelberg, Germany) for 1 h at 22°C, followed by incubation with biotinylated secondary goat anti-rat IgG Abs (Dako, Glostrup, Denmark).

Localization (directed) of Gr-1 in macrophages

7) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.46 Pain Relevance 0.14

g/ml primary rat mAbs directed against mouse Mac-1 (macrophages and neutrophil granulocytes; Medac, Wedel, Germany) or Gr-1 (neutrophil granulocytes; BD Biosciences, Heidelberg, Germany) for 1 h at 22°C, followed by incubation with biotinylated secondary goat anti-rat IgG Abs (Dako, Glostrup, Denmark).

Localization (directed) of Gr-1 in neutrophil

8) Confidence 0.04 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.46 Pain Relevance 0.14

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