INT209439

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.25
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr)
cytoplasm (Gsr)
Anatomy Link Frequency
macrophages 1
monocytes 1
dendritic cells 1
neutrophil 1
mononuclear phagocytes 1
Gsr (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 204 98.58 Very High Very High Very High
Inflammation 299 93.24 High High
fibrosis 2 78.20 Quite High
chemokine 61 66.76 Quite High
Arthritis 112 59.68 Quite High
withdrawal 6 56.88 Quite High
aspirin 8 53.60 Quite High
ischemia 8 50.00 Quite Low
agonist 26 47.24 Quite Low
COX-2 inhibitor 2 45.12 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 15 97.76 Very High Very High Very High
Apoptosis 40 97.56 Very High Very High Very High
Mycobacterial Infection 147 95.20 Very High Very High Very High
INFLAMMATION 321 93.24 High High
Death 3 91.48 High High
Injury 22 90.96 High High
Hypercalcemia 20 82.04 Quite High
Infection 113 79.60 Quite High
Fibrosis 2 78.20 Quite High
Hyperplasia 2 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The numbers of CD11b+ monocytes, and Gr1+ granulocytes were not modified.
Localization (granulocytes) of Gr1 in monocytes
1) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.14 Pain Relevance 0.03
In contrast, in spleen, the numbers of B220+ B lymphocytes, CD11b+ monocytes, CD11c+ dendritic cells and Gr1+ granulocytes were similar in both K?
Localization (granulocytes) of Gr1 in dendritic cells
2) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.13 Pain Relevance 0.03
To investigate the possible effects of MC3R gene ablation on adhesion molecule expression on circulating leukocytes during I/R, we investigated the expression of CD11b and CD62L on granulocytes (GR-1hi) and mononuclear phagocytes (F4/80+).
Localization (granulocytes) of GR-1hi in mononuclear phagocytes associated with adhesions
3) Confidence 0.22 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.27 Pain Relevance 0.03
For this reason, we experimentally determined the timing of accumulation of Gr1+ neutrophilic population (CD11b+ Gr1+) (Figure 5a) [68] and Gr1+ monocytic population (CD11b?
Localization (population) of Gr1
4) Confidence 0.17 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.97 Pain Relevance 0.17
Peritoneal cells collected from mice receiving lidocaine (at both 0.08% and 0.008%) together with zymosan showed significantly decreased annexin-V+Gr-1+ cells by 50% and 64%, respectively, indicating reduced PMN apoptosis (Fig. 3A).
Localization (decreased) of Gr-1 associated with apoptosis and lidocaine
5) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.49 Pain Relevance 0.82
Cells with positive staining of both F4/80 and Gr-1 were then monitored by FACS analysis.
Localization (staining) of Gr-1 in F4/80
6) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.33 Pain Relevance 0.64
g/ml primary rat mAbs directed against mouse Mac-1 (macrophages and neutrophil granulocytes; Medac, Wedel, Germany) or Gr-1 (neutrophil granulocytes; BD Biosciences, Heidelberg, Germany) for 1 h at 22°C, followed by incubation with biotinylated secondary goat anti-rat IgG Abs (Dako, Glostrup, Denmark).
Localization (directed) of Gr-1 in macrophages
7) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.46 Pain Relevance 0.14
g/ml primary rat mAbs directed against mouse Mac-1 (macrophages and neutrophil granulocytes; Medac, Wedel, Germany) or Gr-1 (neutrophil granulocytes; BD Biosciences, Heidelberg, Germany) for 1 h at 22°C, followed by incubation with biotinylated secondary goat anti-rat IgG Abs (Dako, Glostrup, Denmark).
Localization (directed) of Gr-1 in neutrophil
8) Confidence 0.04 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.46 Pain Relevance 0.14

General Comments

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