INT20944

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 5.96
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mcf2l) intracellular (Mcf2l) cytoplasm (Mcf2l)
Anatomy Link Frequency
nucleus accumbens 1
brain 1
Mcf2l (Mus musculus)
Pain Link Frequency Relevance Heat
deep brain stimulation 219 100.00 Very High Very High Very High
Pain 32 100.00 Very High Very High Very High
Nucleus accumbens 3 99.68 Very High Very High Very High
Thalamus 7 97.52 Very High Very High Very High
central pain 2 93.84 High High
anesthesia 11 89.84 High High
imagery 122 80.36 Quite High
depression 9 75.28 Quite High
Dorsal column 2 69.12 Quite High
cingulotomy 1 65.20 Quite High
Disease Link Frequency Relevance Heat
Pain 28 100.00 Very High Very High Very High
Dyskinesias 33 99.88 Very High Very High Very High
Parkinson's Disease 28 99.84 Very High Very High Very High
Emergencies 6 99.68 Very High Very High Very High
Anxiety Disorder 213 98.32 Very High Very High Very High
Disease 101 95.68 Very High Very High Very High
Tremor 16 88.84 High High
Injury 2 88.32 High High
Dystonia 22 88.12 High High
Neurological Disease 2 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although DBS is supposed to be as effective in elderly patients as in younger ones, systematic studies on the complication rate, the effectiveness and therefore the risk-benefit ratio of DBS in elderly patients are still lacking.
Gene_expression (effective) of DBS associated with deep brain stimulation
1) Confidence 0.58 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1847528 Disease Relevance 0.26 Pain Relevance 0.30
However, the effect of STN DBS on the pain in PD is only partially investigated.
Spec (investigated) Gene_expression (effect) of DBS associated with parkinson's disease and pain
2) Confidence 0.58 Published 2008 Journal J. Neurol. Section Abstract Doc Link 19159059 Disease Relevance 0.91 Pain Relevance 0.44
METHODS: PD patients who were considered for STN DBS were asked if they had pain.
Gene_expression (asked) of DBS
3) Confidence 0.51 Published 2008 Journal J. Neurol. Section Body Doc Link 19159059 Disease Relevance 0.19 Pain Relevance 0
Stimulation at 50 mA produced median visual analog scale scores of 7.5, 7.0, and 5.0 for DBS3,2, DBS3,3, and TOF, respectively.
Gene_expression (produced) of DBS3
4) Confidence 0.48 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2160781 Disease Relevance 0 Pain Relevance 0
Stimulation at 50 mA produced median visual analog scale scores of 7.5, 7.0, and 5.0 for DBS3,2, DBS3,3, and TOF, respectively.
Gene_expression (produced) of DBS3
5) Confidence 0.48 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2160781 Disease Relevance 0 Pain Relevance 0
Therefore, our aim in this paper was to elucidate the number and nature of DBS and non-DBS presentations to the emergency department (ED) and to educate and familiarize ED physicians about DBS devices and their potential complications.
Gene_expression (presentations) of DBS associated with emergencies and deep brain stimulation
6) Confidence 0.46 Published 2010 Journal J. Neurol. Section Abstract Doc Link 19813069 Disease Relevance 0.62 Pain Relevance 0.45
Therefore, our aim in this paper was to elucidate the number and nature of DBS and non-DBS presentations to the emergency department (ED) and to educate and familiarize ED physicians about DBS devices and their potential complications.
Gene_expression (devices) of DBS associated with emergencies and deep brain stimulation
7) Confidence 0.46 Published 2010 Journal J. Neurol. Section Abstract Doc Link 19813069 Disease Relevance 0.60 Pain Relevance 0.47
In comparison to the DBS procedure without MER, the time needed for the test procedure was thereafter reduced significantly, as stimulation was only started in two or three channels that had sufficient MER activity.
Gene_expression (procedure) of DBS associated with deep brain stimulation
8) Confidence 0.30 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0 Pain Relevance 0.14
All the patients gave informed consent for the surgical DBS procedure including MER.
Gene_expression (procedure) of DBS associated with deep brain stimulation
9) Confidence 0.30 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0.66 Pain Relevance 0.47
Positioning of DBS targets from MER
Gene_expression (targets) of DBS associated with deep brain stimulation
10) Confidence 0.30 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0 Pain Relevance 0.09
METHODS: Following informed consent, a patient with OPT (and failure of multiple classes of medication and botulinum toxin therapy) underwent placement of bilateral DBS electrodes within the region of the RN.
Gene_expression (electrodes) of DBS
11) Confidence 0.30 Published 2009 Journal Parkinsonism Relat. Disord. Section Body Doc Link 18395484 Disease Relevance 0.07 Pain Relevance 0
Reviewing the first 60 patients with NIP submitted to deep brain stimulation (DBS) from 1978 to 1991 at the Division of Neurosurgery, Toronto Hospital, University of Toronto, we observed that 6 patients complained of unpleasant paresthesiae with paresthesiae-producing DBS, preventing permanent electrode implantation in all of them.
Gene_expression (producing) of DBS in brain associated with pain and deep brain stimulation
12) Confidence 0.12 Published 1996 Journal Arq Neuropsiquiatr Section Abstract Doc Link 8736146 Disease Relevance 0.60 Pain Relevance 0.77
In an attempt to improve patient selection, we reviewed our patients considering a number of parameters in order to determine risk factors for unpleasant paresthesiae elicited by paresthesiae-producing DBS.
Gene_expression (producing) of DBS associated with deep brain stimulation
13) Confidence 0.12 Published 1996 Journal Arq Neuropsiquiatr Section Abstract Doc Link 8736146 Disease Relevance 0.82 Pain Relevance 1.02
Additional studies have shown effectiveness of DBS in the nucleus accumbens (NAc) region in OCD [61, 62], and an investigation into the detailed mechanism of NAc DBS in rats found that activity in orbitofrontal cortex was reduced through a complex form of recurrent inhibition involving antidromic activation of cortico-striatal axon collaterals [63]

OCD Precipitated by Basal Ganglia Disruptions

Gene_expression (effectiveness) of DBS in nucleus accumbens associated with nucleus accumbens, deep brain stimulation and anxiety disorder
14) Confidence 0.10 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.83 Pain Relevance 0.49
For both TOF stimulation and DBS, the response to the stimuli in a series fades such that the last response can be expressed as a ratio of the first.
Gene_expression (expressed) of DBS
15) Confidence 0.08 Published 1999 Journal Am J Health Syst Pharm Section Abstract Doc Link 10437711 Disease Relevance 0 Pain Relevance 0.08
Abnormal movements were reduced only by DBS.
Gene_expression (reduced) of DBS associated with dyskinesias
16) Confidence 0.04 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654791 Disease Relevance 0.41 Pain Relevance 0.03

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