INT209442

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.09
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ssr4) molecular_function (Ssr4) biological_process (Ssr4)
Anatomy Link Frequency
lymphocytes 2
platelets 1
osteoclasts 1
Ssr4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 74.08 Quite High
Catecholamine 2 73.04 Quite High
Kinase C 2 29.68 Quite Low
Versed 6 15.52 Low Low
cva 17 5.00 Very Low Very Low Very Low
withdrawal 11 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 30 94.52 High High
Critical Illness 6 50.00 Quite Low
Sleep Disorders 1 18.64 Low Low
Brain Injury 21 5.00 Very Low Very Low Very Low
Osteopetrosis 18 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 15 5.00 Very Low Very Low Very Low
Osteoporosis 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when lymphocytes were present in large amounts, we noticed a significant increase in TRAP activity, since 20% of cells in culture were TRAP+.
Positive_regulation (increase) of TRAP in lymphocytes
1) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0.04
75 mouse splenocytes and TRAP activity is increased in the presence of lymphocytes.
Positive_regulation (increased) of TRAP in lymphocytes
2) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.09 Pain Relevance 0
Among these, multinucleated TRAP+ osteoclasts were identified, representing a third of the total number of multinucleated cells formed with WT precursors but containing, on average, 7 nuclei versus 20 in controls (Figures 2A and 2B).
Positive_regulation (multinucleated) of TRAP in osteoclasts
3) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0.04
The fact that isolated platelets exhibited a temporally differentiated response to the same norepinephrine concentration in the first versus second week coinciding with a preserved and even increased TRAP-mediated platelet activation suggests altered susceptibility of platelet receptors.
Positive_regulation (increased) of TRAP in platelets
4) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0 Pain Relevance 0.04

General Comments

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