INT209443

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.45
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Tyrobp)
Anatomy Link Frequency
lymphocytes 2
osteoclasts 2
accessory cells 1
myeloid cell 1
spleen 1
Tyrobp (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 40 97.72 Very High Very High Very High
Arthritis 74 94.76 High High
cytokine 42 94.04 High High
rheumatoid arthritis 23 92.92 High High
Inflammation 72 75.00 Quite High
imagery 13 57.52 Quite High
withdrawal 21 11.44 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 84 99.06 Very High Very High Very High
Congenital Anomalies 2 98.40 Very High Very High Very High
Osteopetrosis 44 97.04 Very High Very High Very High
Arthritis 106 94.76 High High
Disease 65 94.24 High High
Rheumatoid Arthritis 23 92.92 High High
Pressure And Volume Under Development 18 80.28 Quite High
INFLAMMATION 60 75.00 Quite High
Injury 4 57.92 Quite High
Osteoporosis 25 42.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, Dap12 complete deletion or Dap12 loss of function (K?
Negative_regulation (loss) of Dap12
1) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.28 Pain Relevance 0
It is required for normal bone homeostasis because mice with impaired DAP12 function, either by targeted inactivation of the ITAM domain or through its complete deletion, develop osteopetrosis after puberty due to the inability of osteoclasts to resorb bone.
Negative_regulation (impaired) of DAP12 in osteoclasts associated with osteopetrosis
2) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.17 Pain Relevance 0.03
During osteoclastogenesis, mature lymphocytes may act as accessory cells in the absence of a functional DAP12 protein.


Negative_regulation (absence) of DAP12 protein in accessory cells
3) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
As lymphocytes compensate for Dap12 deficiency for in vitro osteoclastogenesis, we decided to evaluate the importance of lymphocytes in the control of bone mass.
Negative_regulation (deficiency) of Dap12 in lymphocytes
4) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
As DAP12 activity protects against bone loss after ovariectomy and lymphocytes seem to play a similar accessory role, we wanted to know whether Dap12 deletion would act independently or synergistically with mature lymphocyte depletion.
Negative_regulation (loss) of DAP12 in lymphocytes
5) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0.03
The protective effect of DAP12 on ovariectomy-induced bone loss has been emphasized since we show here that bone resorption activity can be restored after ovariectomy of Dap12 loss of function mutant mice.
Negative_regulation (loss) of Dap12 associated with hypercalcemia
6) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.19 Pain Relevance 0.05
In order to analyze the role of lymphocytes in osteoclast differentiation, we performed in vitro osteoclast differentiation from spleen cells from Dap12 loss of function K?
Negative_regulation (loss) of Dap12 in spleen
7) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0.05
Also, myeloid cell–specific genes including CD11b, RANK, and DAP12 are reduced in the MDL-1–Ig fusion group and elevated in anti–MDL-1 agonist group.
Negative_regulation (reduced) of DAP12 in myeloid cell associated with agonist
8) Confidence 0.33 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.42 Pain Relevance 0.29
Absence of functional Dap12 results in osteoclast defects and bone abnormalities.
Negative_regulation (Absence) of Dap12 in osteoclast associated with congenital anomalies
9) Confidence 0.29 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.38 Pain Relevance 0.11

General Comments

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