INT209451

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63)
Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)
Anatomy Link Frequency
uterine 2
lung 2
TP63 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 68 50.00 Quite Low
metalloproteinase 1 45.08 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leiomyosarcoma 72 100.00 Very High Very High Very High
Apoptosis 4 100.00 Very High Very High Very High
Cancer 77 99.60 Very High Very High Very High
Metastasis 10 98.32 Very High Very High Very High
Endometrial Cancer 1 89.20 High High
Reprotox - General 1 3 88.12 High High
Thrombocytopenia 1 87.88 High High
Neutropenia 5 87.04 High High
Fatigue 2 84.60 Quite High
Solid Tumor 6 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three patients on this study had discernable antitumor activity, one of which was a uterine LMS patient, who experienced a 41% reduction in lung metastases and a 27% overall tumor response after four courses of 325 ?
Regulation (uterine) of Gene_expression (patient) of LMS in lung associated with leiomyosarcoma, cancer and metastasis
1) Confidence 0.16 Published 2010 Journal Core evidence Section Body Doc Link PMC2899778 Disease Relevance 1.66 Pain Relevance 0
COX-2, p63 and PCNA expression in preneoplastic lesions in the NNK-treated rats
Regulation (lesions) of Gene_expression (expression) of p63
2) Confidence 0.08 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.45 Pain Relevance 0
COX-2, p63 and PCNA expression in preneoplastic lesions in the NNK-treated rats
Regulation (treated) of Gene_expression (expression) of p63
3) Confidence 0.08 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.46 Pain Relevance 0
As apoptotic mechanisms have also been implicated in many human cancers, investigating the dysregulation of the expression of apoptotic and/or cell-cycle regulators in uterine LMS is required to identify molecular pathways that could possibly be important in the development of human uterine LMS.
Spec (investigating) Regulation (dysregulation) of Gene_expression (expression) of LMS in uterine associated with leiomyosarcoma, cancer and apoptosis
4) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 1.74 Pain Relevance 0

General Comments

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