INT20950

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.76
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PC) small molecule metabolic process (PC) carbohydrate metabolic process (PC)
ligase activity (PC)
Anatomy Link Frequency
blood 3
colon 1
heart 1
PC (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurobehavioral 75 94.96 High High
alcohol 48 94.52 High High
depression 63 89.88 High High
Dopamine 57 89.12 High High
Nicotine 12 87.44 High High
halothane 3 85.12 High High
anesthesia 3 84.32 Quite High
Potency 13 74.52 Quite High
antidepressant 6 71.64 Quite High
Arthritis 3 66.16 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 3 100.00 Very High Very High Very High
Colon Cancer 27 98.40 Very High Very High Very High
Loss Of Sense Of Smell 27 96.60 Very High Very High Very High
Toxicity 63 95.48 Very High Very High Very High
Cognitive Disorder 61 94.32 High High
Intellectual Impairment 120 94.04 High High
Breast Cancer 3 93.28 High High
Attention Deficit Hyperactivity Disorder 22 93.04 High High
Depression 81 91.68 High High
Nicotine Addiction 29 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a pooled analysis of the current blood samples showed no significant increase of the planar PCB 77, 126 and 169 as well as dioxins [65] suggesting that our results are unlikely to be biased by dioxin-related toxicity.
Neg (no) Positive_regulation (increase) of PCB in blood associated with toxicity
1) Confidence 0.60 Published 2005 Journal Environ Health Section Body Doc Link PMC1277834 Disease Relevance 0.19 Pain Relevance 0.04
A significant model for predicting blood values (which were dichotomized at the median of controls) could only be generated for PCB 28 (?
Positive_regulation (generated) of PCB in blood
2) Confidence 0.60 Published 2005 Journal Environ Health Section Body Doc Link PMC1277834 Disease Relevance 0 Pain Relevance 0.09
Such an elevation of nutritional PCBs could not be confirmed for PCB or control subjects reporting greater consumption of fish.
Neg (not) Positive_regulation (confirmed) of PCB
3) Confidence 0.44 Published 2005 Journal Environ Health Section Body Doc Link PMC1277834 Disease Relevance 0.16 Pain Relevance 0.11
Figure 1 shows aggregated exposure measures for contaminated rooms indicating increased PCB values for the congeners 28, 52 and 101.
Positive_regulation (increased) of PCB
4) Confidence 0.44 Published 2005 Journal Environ Health Section Body Doc Link PMC1277834 Disease Relevance 0.07 Pain Relevance 0.07
Despite low current consumption rates, serum PCB levels tended to increase with estimated cumulative lifetime exposure to PCBs from Hudson River fish consumption.
Positive_regulation (increase) of PCB
5) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2235204 Disease Relevance 0.37 Pain Relevance 0.08
Specifically, an increase in serum total PCB concentration from 250 to 500 ppb (lipid basis) was associated with a 6.2% mean decrease in performance.
Positive_regulation (increase) of PCB
6) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2235204 Disease Relevance 0.68 Pain Relevance 0.26
Re-analysis of subgroup with elevated PCB 28 blood levels
Positive_regulation (elevated) of PCB in blood
7) Confidence 0.40 Published 2005 Journal Environ Health Section Body Doc Link PMC1277834 Disease Relevance 0.21 Pain Relevance 0.05
Elevated PCB values were confirmed for low chlorinated congeners such as PCB 28, thus corresponding to previous reports [29,65].
Positive_regulation (Elevated) of PCB
8) Confidence 0.40 Published 2005 Journal Environ Health Section Body Doc Link PMC1277834 Disease Relevance 0 Pain Relevance 0.05
After adjustment for potential confounders, the results indicated that an increase in serum total PCB concentration from 250 to 500 ppb (lipid basis) was associated with a 6.2% decrease in verbal learning, as measured by California Verbal Learning Test trial 1 score (p = 0.035), and with a 19.2% increase in depressive symptoms, as measured by the Beck Depression Inventory (p = 0.007).


Positive_regulation (increase) of PCB associated with depression
9) Confidence 0.39 Published 2008 Journal Environ Health Perspect Section Abstract Doc Link PMC2235204 Disease Relevance 0.58 Pain Relevance 0.08
The proportion of studies using developmental models instead of adult testing increased gradually in PCB studies (?
Positive_regulation (increased) of PCB
10) Confidence 0.39 Published 2008 Journal Environ Health Section Body Doc Link PMC2596097 Disease Relevance 0 Pain Relevance 0
No significant change in heart rate or blood pressure was observed with PPB but with PCB a significant increase in heart rate was observed.
Positive_regulation (increase) of PCB in heart associated with heart rate under development
11) Confidence 0.36 Published 1990 Journal Masui Section Abstract Doc Link 2161058 Disease Relevance 0.10 Pain Relevance 0.36
Nevertheless, higher serum levels of PCB-28 were associated with increased risk of colon cancer in this study.
Positive_regulation (levels) of PCB-28 in colon associated with colon cancer
12) Confidence 0.29 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.40 Pain Relevance 0

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