INT209501

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 20.70
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CADPS) cytosol (CADPS)
Anatomy Link Frequency
blood 2
brachial artery 1
platelets 1
articular 1
leukocytes 1
CADPS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 154 99.72 Very High Very High Very High
Pain 56 98.84 Very High Very High Very High
Inflammatory response 30 97.64 Very High Very High Very High
Inflammatory stimuli 9 94.20 High High
abdominal pain 4 91.60 High High
bradykinin 45 90.48 High High
depression 32 86.16 High High
headache 35 85.56 High High
cva 63 85.12 High High
Arthritis 6 84.76 Quite High
Disease Link Frequency Relevance Heat
Syndrome 399 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 87 99.98 Very High Very High Very High
Anti-phospholipid Antibody Syndrome 238 99.96 Very High Very High Very High
INFLAMMATION 167 99.72 Very High Very High Very High
Acute Cholecystitis 2 99.70 Very High Very High Very High
Exanthema 33 99.68 Very High Very High Very High
Amyloidosis 32 99.32 Very High Very High Very High
Pain 50 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 72 98.04 Very High Very High Very High
Cryopyrin-associated Periodic Syndromes 127 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although CAPs exposure did not affect endothelium-dependent or independent vasodilatation in Brook et al.’s study, it did induce vasoconstriction of the brachial artery.
Gene_expression (exposure) of CAPs in brachial artery associated with increased venous pressure under development
1) Confidence 0.65 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 0.31 Pain Relevance 0
Average PM concentrations in the CAPs exposures (190 ± 37 ?
Gene_expression (exposures) of CAPs
2) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 0.29 Pain Relevance 0.07
We found no correlation between peak forearm blood flow and particle mass or particle number in the CAPs exposure for any of the vasodilators infused.


Gene_expression (exposure) of CAPs in blood
3) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 0.26 Pain Relevance 0.13
To maximize differences in exposure and minimize the influence of ambient pollution, most CAPs exposures were conducted when ambient pollution levels were high.
Gene_expression (exposures) of CAPs
4) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 0.05 Pain Relevance 0.06
It is possible that our CAPs exposures would have induced similar effects on conduit arterial tone because this may not be reflected in changes in basal forearm blood flow measured by venous occlusion plethysmography.
Gene_expression (exposures) of CAPs in blood
5) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 0.25 Pain Relevance 0
The VACES system does not include particles < 15 nm in the exposure atmosphere, and the mean particle size in a typical CAPs exposure was 1.23 ± 0.4 ?
Gene_expression (exposure) of CAPs
6) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 0.22 Pain Relevance 0.08
We did not find a consistent systemic inflammatory signal after CAPs exposure: there were no changes in the numbers of circulating neutrophils, lymphocytes, or total leukocytes, even up to 24 hr.
Gene_expression (exposure) of CAPs in leukocytes associated with inflammation
7) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 0.79 Pain Relevance 0.18
We found no significant differences between concentrations of gaseous copollutants between the filtered air or CAPs exposures (Table 2).
Gene_expression (exposures) of CAPs
8) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 0.24 Pain Relevance 0.06
The number of circulating platelets increased 2 hr after CAPs exposure, and a similar transient effect on circulating monocytes was present at 6 hr.
Gene_expression (exposure) of CAPs in platelets
9) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430224 Disease Relevance 1.02 Pain Relevance 0.22
Cardiff Anomalous Perceptions Scale (CAPS; Bell et al.
                           2006)
Gene_expression (al.) of CAPS
10) Confidence 0.53 Published 2008 Journal Psychological Medicine Section Body Doc Link PMC2830058 Disease Relevance 0.17 Pain Relevance 0
Etiology and pathogenesis of CAPS
Gene_expression (pathogenesis) of CAPS associated with syndrome
11) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880341 Disease Relevance 2.36 Pain Relevance 0.20
NOMID, termed in Europe chronic infantile neurologic, cutaneous, articular syndrome (CINCA), is the most severe of the CAPS.
Gene_expression (severe) of CAPS in articular associated with cryopyrin-associated periodic syndromes and syndrome
12) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880341 Disease Relevance 3.05 Pain Relevance 0.29
The three autosomal-dominant syndromes that constitute CAPS are caused by single base mutations on the NLRP3 gene located on the long arm of chromosome 1 encoding the protein cryopyrin.1,3,8 Some mutations are specific to one of the syndromes and some overlap among all three syndromes (Table 1a).1,9 Often, especially in patients with NOMID, no mutations are found, thus it is clear that other factors influence the development and severity of CAPS.9
Neg (no) Gene_expression (caused) of CAPS in arm associated with cryopyrin-associated periodic syndromes and syndrome
13) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880341 Disease Relevance 2.31 Pain Relevance 0.19
Urticarial-like skin rash is universally present in all CAPS patients.
Gene_expression (present) of CAPS in skin associated with exanthema and syndrome
14) Confidence 0.43 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 2.63 Pain Relevance 0
Women with a PTSD diagnosis on the CAPS endorsed significantly more pain after the procedure at both 1 month (With PTSD: 7.0 ± 3.3; Without PTSD: 3.9 ± 2.5; p = 0.049), and 3 months (With PTSD: 8.0 ± 2.4; Without PTSD: 3.7 ± 2.4; p = 0.012).
Gene_expression (diagnosis) of CAPS associated with pain and post-traumatic stress disorder
15) Confidence 0.13 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1899490 Disease Relevance 2.74 Pain Relevance 0.35
Acute cholecystitis has also been observed in CAPS patients.96 Last but not least, an occlusion of the splenic vessels was parallel to other vascular occlusions.97 However, splenic infarction/splenic atrophy are rare events, although at least one SLE patient with these complaints has been reported.98

Malignant diseases

Neg (not) Gene_expression (observed) of CAPS in vessels associated with malignant neoplastic disease, splenic infarction, frailty, disease, systemic lupus erythematosus and acute cholecystitis
16) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.36 Pain Relevance 0.35
Rapid chronological occlusive events, occurring over days to weeks, have been referred to as "catastrophic" APS (CAPS).22
Gene_expression (.22) of CAPS associated with anti-phospholipid antibody syndrome
17) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.63 Pain Relevance 0.04

General Comments

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