INT209517

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 16
Disease Relevance 8.26
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 10
epithelium 4
Muc5ac (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 90.88 High High
Inflammation 135 86.48 High High
addiction 12 84.20 Quite High
Inflammatory response 10 78.40 Quite High
cytokine 16 77.52 Quite High
fibrosis 45 71.60 Quite High
ketamine 12 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
corticosteroid 11 5.00 Very Low Very Low Very Low
Inflammatory mediators 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 58 99.62 Very High Very High Very High
Smoke Inhalation Injury 180 99.04 Very High Very High Very High
Asthma 62 97.84 Very High Very High Very High
Pulmonary Disease 126 97.28 Very High Very High Very High
Targeted Disruption 12 96.68 Very High Very High Very High
Injury 108 95.08 Very High Very High Very High
Burns 48 90.04 High High
Fibrosis 3 87.76 High High
Occupational Lung Diseases 2 87.44 High High
INFLAMMATION 153 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only MUC5AC gene expression, which was also evaluated by immunoblotting (Figure 3) and immunohistochemistry (Figure 4), was found to be increased in the wild-type mice subjected to smoke inhalation.
Positive_regulation (increased) of Gene_expression (expression) of MUC5AC
1) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0 Pain Relevance 0.03
In the present study, MUC5AC protein expression was increased within 4 hour after 15 min smoke inhalation.
Positive_regulation (increased) of Gene_expression (expression) of MUC5AC
2) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.63 Pain Relevance 0.09
Four and twenty-four hours after exposure to smoke from burning cotton, we observed that MUC5AC mRNA levels were elevated in the mouse lungs, and MUC5AC protein was expressed predominantly in the surface cells of the mouse airway.
Positive_regulation (elevated) of Gene_expression (levels) of MUC5AC mRNA in lungs
3) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.54 Pain Relevance 0.07
P. aeruginosa lung infection did not appear to impact Muc5ac expression over time, regardless of diet.
Positive_regulation (impact) of Gene_expression (expression) of Muc5ac in lung associated with infection
4) Confidence 0.47 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.18 Pain Relevance 0
In our mouse model, we followed Muc5b, Muc5ac and Muc4 while the Muc2 messenger was barely undetectable in lung tissue and did not show any variation prior or after instillation by sterile or PAO1-laden agarose beads (data not shown).
Positive_regulation (followed) of Gene_expression (followed) of Muc5ac in lung
5) Confidence 0.47 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.19 Pain Relevance 0
In this study, we showed that MUC5AC protein overexpression in response to cotton smoke inhalation is tightly regulated via the JNK signaling pathways.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MUC5AC
6) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.36 Pain Relevance 0
Smoke exposure caused an increase in the production of mucus in the airway epithelium of the mice along with an increase in MUC5AC gene and protein expression, while the expression of MUC5B was not increased compared with control.
Positive_regulation (increase) of Gene_expression (expression) of MUC5AC in epithelium
7) Confidence 0.44 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.63 Pain Relevance 0
However, overproduction of mucus and increased MUC5AC protein expression induced by smoke inhalation was suppressed in the JNK inhibitor-treated mice and the JNK1 knockout mice.
Positive_regulation (increased) of Gene_expression (expression) of MUC5AC associated with targeted disruption
8) Confidence 0.44 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.60 Pain Relevance 0
We found increased MUC5AC protein expression in the airway epithelium of the WT mice groups both 4 and 24 h after smoke inhalation injury.
Positive_regulation (increased) of Gene_expression (expression) of MUC5AC in epithelium associated with smoke inhalation injury
9) Confidence 0.44 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.62 Pain Relevance 0
However, overproduction of mucus and increased MUC5AC protein expression induced by smoke inhalation was suppressed in the JNK inhibitor-treated mice and the JNK1 knockout mice.
Positive_regulation (induced) of Gene_expression (expression) of MUC5AC associated with targeted disruption
10) Confidence 0.44 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.60 Pain Relevance 0
An increase in epithelial MUC5AC protein expression is associated with the overproduction of mucus in smoke inhalation injury, and that its expression is related on JNK1 signaling.



Positive_regulation (increase) of Gene_expression (expression) of MUC5AC associated with smoke inhalation injury
11) Confidence 0.44 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.53 Pain Relevance 0
Smoke-induced phosphorylation of JNK suggested that this kinase might participate in the induction of MUC5AC gene expression in the lung cells.
Positive_regulation (induction) of Gene_expression (expression) of MUC5AC in lung
12) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.34 Pain Relevance 0.05
MUC5AC gene expression was found to be increased 4 h after smoke exposure, and it remained elevated throughout the 24-h recovery period.
Positive_regulation (increased) of Gene_expression (expression) of MUC5AC
13) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.43 Pain Relevance 0.03
The expression level of Muc4 in lung of healthy mice was higher than the expression levels of both Muc5b and Muc5ac RNAs.
Positive_regulation (higher) of Gene_expression (expression) of Muc5ac in lung
14) Confidence 0.44 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
In our mouse model of smoke inhalation injury, we found that smoke inhalation induced the mucus overproduction was associated with an increase in epithelial MUC5AC protein expression, and this was dependent on the activation of the JNK pathway.
Positive_regulation (increase) of Gene_expression (expression) of MUC5AC associated with smoke inhalation injury
15) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.51 Pain Relevance 0.07
At least in vitro, epidermal growth factor stimulates MUC5AC mRNA and protein expression; this can be reversed by PDE 4 inhibitors, which may contribute to their clinical efficacy in COPD and asthma (Mata et al 2005).
Positive_regulation (stimulates) of Gene_expression (expression) of MUC5AC mRNA associated with asthma and pulmonary disease
16) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 2.09 Pain Relevance 0.17

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