INT209518

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Muc4) endoplasmic reticulum (Muc4) protein complex (Muc4)
cytoplasm (Muc4)
Muc4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 45 65.08 Quite High
Inflammatory mediators 9 61.08 Quite High
fibrosis 42 48.60 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 57 99.90 Very High Very High Very High
Disease 36 69.80 Quite High
INFLAMMATION 57 65.08 Quite High
Superinfection 6 50.20 Quite High
Pseudomonas Infection 12 49.56 Quite Low
Cystic Fibrosis 42 48.60 Quite Low
Respiratory Disease 3 45.60 Quite Low
Pulmonary Disease 18 5.00 Very Low Very Low Very Low
Dislocations 6 5.00 Very Low Very Low Very Low
Airway Obstruction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inoculation with sterile agarose beads induced a significant downregulation of Muc4 and an upregulation of Muc5b (Figure 3).
Negative_regulation (downregulation) of Muc4
1) Confidence 0.56 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
Figure 2 shows the relative copy numbers of Muc4, Muc5b and Muc5ac normalized with the 18s for mice fed with the three diets.
Negative_regulation (numbers) of Muc4
2) Confidence 0.41 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
These deregulations are modulated by dietary fatty acids with a suppressive effect of n-3 PUFAs on mucin (increase of Muc5b from 19-fold up to 3.6 × 105-fold for the n-3 PUFAs treated group and the control groups, respectively, 4 days post-infection and decrease of Muc4 from 15-fold up to 3.2 × 104-fold for the control and the n-3 PUFAs treated groups, respectively, 4 days post-infection).


Negative_regulation (decrease) of Muc4 associated with infection
3) Confidence 0.41 Published 2007 Journal Respir Res Section Abstract Doc Link PMC1899493 Disease Relevance 0.75 Pain Relevance 0.15

General Comments

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