INT209528

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Muc4) endoplasmic reticulum (Muc4) protein complex (Muc4)
cytoplasm (Muc4)
Anatomy Link Frequency
lung 1
Muc4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 30 32.16 Quite Low
corticosteroid 2 15.12 Low Low
fibrosis 28 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 38 95.12 Very High Very High Very High
Metaplasia 2 85.04 High High
Asthma 2 57.36 Quite High
Disease 24 46.16 Quite Low
Bacterial Infection 2 38.68 Quite Low
INFLAMMATION 38 32.16 Quite Low
Cystic Fibrosis 28 5.00 Very Low Very Low Very Low
Pulmonary Disease 12 5.00 Very Low Very Low Very Low
Pseudomonas Infection 8 5.00 Very Low Very Low Very Low
Dislocations 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAO1 lung inoculation induced two opposite expression patterns of Muc5b and Muc4: Muc5b is highly upregulated with a peak at day 4 showing a suppressive effect of n-3 PUFAs on the Muc5b response to the infection while Muc4 expression decreased to the lowest level at days 1 or 4 for sterile beads and at day 7 for Pseudomonas-laden agarose beads.
Positive_regulation (induced) of Muc4 in lung associated with infection
1) Confidence 0.48 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.24 Pain Relevance 0
At day 7, the level of Muc4 increased towards its baseline level (day 0).
Positive_regulation (increased) of Muc4
2) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0

General Comments

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