INT209537

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 21
Disease Relevance 6.54
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Muc4) endoplasmic reticulum (Muc4) protein complex (Muc4)
cytoplasm (Muc4)
Anatomy Link Frequency
lung 8
epithelium 2
Muc4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 222 94.60 High High
fibrosis 196 92.28 High High
imagery 5 43.28 Quite Low
addiction 5 39.60 Quite Low
corticosteroid 14 27.36 Quite Low
ketamine 5 26.48 Quite Low
Inflammatory mediators 42 25.36 Quite Low
anesthesia 5 25.28 Quite Low
cytokine 28 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 126 100.00 Very High Very High Very High
Metastasis 36 100.00 Very High Very High Very High
Infection 266 99.86 Very High Very High Very High
Pancreatic Cancer 56 98.82 Very High Very High Very High
Disease 176 98.70 Very High Very High Very High
Targeted Disruption 5 98.40 Very High Very High Very High
Asthma 19 98.36 Very High Very High Very High
Injury 45 97.32 Very High Very High Very High
INFLAMMATION 278 94.60 High High
Cystic Fibrosis 196 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we showed in mouse lung that Muc4 is highly expressed in comparison to Muc5b and Muc5ac.
Gene_expression (expressed) of Muc4 in lung
1) Confidence 0.74 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.23 Pain Relevance 0
Membrane-bound Muc4 expression decreased over time (Figure 4).
Gene_expression (expression) of Muc4
2) Confidence 0.74 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.10 Pain Relevance 0
The expression level of Muc4 in lung of healthy mice was higher than the expression levels of both Muc5b and Muc5ac RNAs.
Gene_expression (expression) of Muc4 in lung
3) Confidence 0.74 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
The expression level of Muc4 in lung of healthy mice was higher than the expression levels of both Muc5b and Muc5ac RNAs.
Gene_expression (expression) of Muc4 in lung
4) Confidence 0.74 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
On the fourth day after infection, the n-3 PUFAs enriched diet has a high suppressive effect on the level expression of Muc4 (p < 0.005).
Gene_expression (expression) of Muc4 associated with infection
5) Confidence 0.74 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.16 Pain Relevance 0
PAO1 lung inoculation induced two opposite expression patterns of Muc5b and Muc4: Muc5b is highly upregulated with a peak at day 4 showing a suppressive effect of n-3 PUFAs on the Muc5b response to the infection while Muc4 expression decreased to the lowest level at days 1 or 4 for sterile beads and at day 7 for Pseudomonas-laden agarose beads.
Gene_expression (expression) of Muc4 in lung associated with infection
6) Confidence 0.74 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.24 Pain Relevance 0
Moreover, we chose an absolute quantification method using primers directed at the 3'-end of the Muc genes with oligonucleotides belonging to different exons while in the previous work authors quantified MUC4 expression using a relative qPCR strategy with oligonucleotides chosen within exon 2 of the gene.
Gene_expression (expression) of MUC4
7) Confidence 0.74 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.23 Pain Relevance 0
PAO1 lung inoculation induced two opposite expression patterns of Muc5b and Muc4: Muc5b is highly upregulated with a peak at day 4 showing a suppressive effect of n-3 PUFAs on the Muc5b response to the infection while Muc4 expression decreased to the lowest level at days 1 or 4 for sterile beads and at day 7 for Pseudomonas-laden agarose beads.
Gene_expression (expression) of Muc4 in lung associated with infection
8) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.24 Pain Relevance 0
In our mouse model, we followed Muc5b, Muc5ac and Muc4 while the Muc2 messenger was barely undetectable in lung tissue and did not show any variation prior or after instillation by sterile or PAO1-laden agarose beads (data not shown).
Gene_expression (followed) of Muc4 in lung
9) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.19 Pain Relevance 0
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Gene_expression (expression) of MUC4
10) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.07 Pain Relevance 0
In the healthy lung, MUC1 and MUC4 are expressed on the apical surface of the respiratory epithelium.
Gene_expression (expressed) of MUC4 in epithelium
11) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.70 Pain Relevance 0.05
In the present smoke inhalation mouse model, we observed no difference in MUC1 and MUC4 protein expression between mice in the control and smoke inhalation groups (Figure 2).
Gene_expression (expression) of MUC4
12) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0 Pain Relevance 0
Many studies have focused on MUC5AC and MUC2 regulation in airway diseases using mainly airway cell and explant cultures [32-34] while the expression of the oligomeric mucin MUC5B and the membrane-bound mucin MUC4 have not yet been investigated.
Gene_expression (expression) of MUC4 associated with disease
13) Confidence 0.58 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.40 Pain Relevance 0.07
At the cellular level, MUC5AC is expressed in the goblet cells of main bronchi and bronchioles and MUC5B is expressed in bronchiolar epithelium and in submucosal gland epithelium while MUC4 transcripts are detected in the epithelium of main bronchi and bronchioles [19-21].
Gene_expression (detected) of MUC4 in epithelium
14) Confidence 0.58 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.26 Pain Relevance 0.03
In human, it has been reported that MUC5AC expression, measured using real-time RT-PCR, is much higher than both MUC5B and MUC4 in homogenates of endobronchial biopsies from healthy subjects or subjects with asthma [40].
Gene_expression (expression) of MUC4 associated with asthma
15) Confidence 0.58 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.18 Pain Relevance 0
MUC5AC, MUC5B and MUC4, which are conserved mucins between human and rodent [30,31], are three predominant large mucins expressed in the lung.
Gene_expression (expressed) of MUC4 in lung
16) Confidence 0.58 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.34 Pain Relevance 0.05
Among the identified mucins, the large anchored-mucin MUC4 and the two large gel-forming mucins MUC5B and MUC5AC seem highly expressed in normal and/or abnormal human lung while MUC2 is almost not detectable [18].
Gene_expression (expressed) of MUC4 in lung
17) Confidence 0.50 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.36 Pain Relevance 0.09
The membrane-associated mucins, MUC1 and MUC4, were found to be highly expressed in both the control and smoke inhalation group mice.
Gene_expression (expressed) of MUC4
18) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.44 Pain Relevance 0.03
Smoke exposure did not alter the expression of MUC1 and MUC4 proteins in all 3 groups compared with control.


Gene_expression (expression) of MUC4
19) Confidence 0.46 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.51 Pain Relevance 0
The pancreatic carcinoma cell markers (cytokeratins, CA 19-9) as well as the other overexpressed proteins identified in PaCa 5061 cell line (MUC 4, EGFR, CEACAM 1, -5, and -6) were analyzed by IHC in mouse primary tumor and corresponding metastasis and compared with the expression of this marker in the primary tumor of the patient.
Gene_expression (expression) of MUC 4 associated with cancer, pancreatic cancer and metastasis
20) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.95 Pain Relevance 0

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