INT209538

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.87
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Muc4) endoplasmic reticulum (Muc4) protein complex (Muc4)
cytoplasm (Muc4)
Anatomy Link Frequency
lung 6
Muc4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 47 64.20 Quite High
fibrosis 42 41.44 Quite Low
addiction 1 39.60 Quite Low
corticosteroid 3 15.12 Low Low
Inflammatory mediators 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 9 97.32 Very High Very High Very High
Infection 57 95.12 Very High Very High Very High
Metaplasia 3 85.04 High High
Asthma 4 84.28 Quite High
Bacterial Infection 3 75.12 Quite High
Bacterial Meningitis 1 74.20 Quite High
INFLAMMATION 59 64.20 Quite High
Smoke Inhalation Injury 15 63.28 Quite High
Disease 36 46.16 Quite Low
Cystic Fibrosis 42 41.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAO1 lung inoculation induced two opposite expression patterns of Muc5b and Muc4: Muc5b is highly upregulated with a peak at day 4 showing a suppressive effect of n-3 PUFAs on the Muc5b response to the infection while Muc4 expression decreased to the lowest level at days 1 or 4 for sterile beads and at day 7 for Pseudomonas-laden agarose beads.
Positive_regulation (induced) of Gene_expression (expression) of Muc4 in lung associated with infection
1) Confidence 0.48 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.24 Pain Relevance 0
In our mouse model, we followed Muc5b, Muc5ac and Muc4 while the Muc2 messenger was barely undetectable in lung tissue and did not show any variation prior or after instillation by sterile or PAO1-laden agarose beads (data not shown).
Positive_regulation (followed) of Gene_expression (followed) of Muc4 in lung
2) Confidence 0.48 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.19 Pain Relevance 0
The expression level of Muc4 in lung of healthy mice was higher than the expression levels of both Muc5b and Muc5ac RNAs.
Positive_regulation (higher) of Gene_expression (expression) of Muc4 in lung
3) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0 Pain Relevance 0
The membrane-associated mucins, MUC1 and MUC4, were found to be highly expressed in both the control and smoke inhalation group mice.
Positive_regulation (highly) of Gene_expression (expressed) of MUC4
4) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.44 Pain Relevance 0.03

General Comments

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