INT209564

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.72
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncoa5) molecular_function (Ncoa5) cellular_component (Ncoa5)
biological_process (Ncoa5)
Anatomy Link Frequency
articular cartilage 1
Ncoa5 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 285 100.00 Very High Very High Very High
rheumatoid arthritis 129 99.92 Very High Very High Very High
Inflammation 175 99.00 Very High Very High Very High
Inflammatory response 6 86.60 High High
cytokine 84 83.88 Quite High
Osteoarthritis 37 63.84 Quite High
cINOD 22 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 345 100.00 Very High Very High Very High
Rheumatoid Arthritis 129 99.92 Very High Very High Very High
Sprains And Strains 1 99.36 Very High Very High Very High
INFLAMMATION 183 99.00 Very High Very High Very High
Immunization 9 97.60 Very High Very High Very High
Autoimmune Disease 12 97.40 Very High Very High Very High
Pressure And Volume Under Development 50 95.52 Very High Very High Very High
Disease 92 95.08 Very High Very High Very High
Apoptosis 13 66.88 Quite High
Osteoarthritis 37 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CIA can be elicited in susceptible strains of rodents and nonhuman primates by immunization with collagen type II, the major matrix constituent protein of articular cartilage.
Positive_regulation (elicited) of CIA in articular cartilage associated with immunization, sprains and strains and arthritis
1) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.97 Pain Relevance 0.35
In contrast, following induction of CIA, mice were randomly assigned to one of 3 therapeutic treatment groups: control-, Perna-, or DMG-treated.
Positive_regulation (induction) of CIA associated with arthritis
2) Confidence 0.04 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1899520 Disease Relevance 0.30 Pain Relevance 0.15
A single intravenous injection of an adenovirus encoding CTLA-4Ig fusion protein suppressed established CIA as least as efficiently as repeated injections of monoclonal antibody to CTLA-4.
Positive_regulation (established) of CIA associated with arthritis
3) Confidence 0.04 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.97 Pain Relevance 0.44
It has previously been suggested that low-affinity antibodies to collagen are necessary for CIA pathogenesis in rats [23], thus DMG may inhibit production of these pathologic antibodies.
Positive_regulation (necessary) of CIA associated with arthritis
4) Confidence 0.03 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1899520 Disease Relevance 0.62 Pain Relevance 0.30
Additionally, the combination of Perna and DMG or DMG alone delayed CIA induction by almost 2 days as compared to the Perna-treated and controls groups.


Positive_regulation (induction) of CIA associated with arthritis
5) Confidence 0.03 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1899520 Disease Relevance 0.90 Pain Relevance 0.24
In subsequent in vivo experiments, CIA was induced by administration of type II collagen; rats were prophylactically treated with either Perna or DMG, and then followed for disease severity.
Positive_regulation (induced) of CIA associated with disease and arthritis
6) Confidence 0.03 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1899520 Disease Relevance 0.95 Pain Relevance 0.42

General Comments

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