INT209565

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2008
Negated 1
Speculated 5
Reported most in Body
Documents 9
Total Number 14
Disease Relevance 5.07
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ik)
Anatomy Link Frequency
macrophage 2
astrocytes 2
adipocytes 2
T lymphocytes 2
Ik (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 589 100.00 Very High Very High Very High
Inflammation 264 100.00 Very High Very High Very High
antagonist 27 98.40 Very High Very High Very High
Potency 5 98.20 Very High Very High Very High
Morphine 156 97.48 Very High Very High Very High
cINOD 12 85.92 High High
psoriasis 4 82.52 Quite High
chemokine 42 73.00 Quite High
rheumatoid arthritis 45 69.52 Quite High
Arthritis 62 68.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 311 100.00 Very High Very High Very High
Obesity 366 99.84 Very High Very High Very High
Disease 90 94.88 High High
Cardiovascular Disorder Under Development 1 91.16 High High
Cytomegalovirus Infection 6 82.60 Quite High
Psoriasis 4 82.52 Quite High
Hypersensitivity 20 77.68 Quite High
Syndrome 3 77.20 Quite High
Injury 7 74.52 Quite High
Targeted Disruption 9 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most specific and potent positive modulator of IK and SK channels characterized so far is NS309, displaying a potency ?
Regulation (modulator) of Gene_expression (channels) of IK associated with potency
1) Confidence 0.14 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.14
However, the loss of effect of Bv8 observed in our PROKR 1 KO mice suggests that PROKR 1 is the main receptor involved in modulating immune responses, which is in line with our previous findings indicating that it is exclusively responsible for mediating the modulation of macrophage cytokine production [19].
Regulation (modulation) of Gene_expression (production) of cytokine in macrophage associated with cytokine
2) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.09
For these reasons, after confirming the presence of PROKRs on splenocyte-derived T lymphocytes, we analysed the effects of the in vitro and in vivo administration of Bv8 on splenocyte cytokine production in mice.
Spec (analysed) Regulation (effects) of Gene_expression (production) of cytokine in T lymphocytes associated with cytokine
3) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.48 Pain Relevance 0.47
B)–dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology.
Regulation (involved) of Gene_expression (expression) of cytokine associated with inflammation and cytokine
4) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2525589 Disease Relevance 0.17 Pain Relevance 0.19
(25 ng/mL), and IL-6 (100 ng/mL) as described.17 Cytokine expression was determined by staining fixed and permeabilized PBL with directly conjugated anticytokine antibodies (all from BD Biosciences PharMingen), after stimulation for 6 hours at 37°C with 20 ng/mL phorbol myristate acetate (PMA) and 200 ng/mL ionomycin (both from Sigma).
Spec (determined) Regulation (determined) of Gene_expression (expression) of Cytokine associated with cytokine
5) Confidence 0.00 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.16 Pain Relevance 0.15
B dimeric complex leading to the regulation of cytokine production.
Regulation (regulation) of Gene_expression (production) of cytokine associated with cytokine
6) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.13 Pain Relevance 0.55
No changes in cytokine production were seen in astrocytes treated with BAPTA/AM or with BAPTA/AM+Ro106-9920 (Fig 5 A–C), suggesting that the IkB?
Neg (No) Regulation (changes) of Gene_expression (production) of cytokine in astrocytes associated with cytokine
7) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.87
Although these studies provide a wealth of data regarding the direct control of cytokine gene expression by the state of NF-?
Regulation (control) of Gene_expression (expression) of cytokine associated with cytokine
8) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 0.33 Pain Relevance 0.19
Studies over the past decade have suggested that purinergic receptor function, involving both P2Y and P2X family members, can modulate cytokine production and/or activity.
Regulation (modulate) of Gene_expression (production) of cytokine associated with cytokine
9) Confidence 0.00 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 1.15 Pain Relevance 0.61
These examples demonstrate important roles of purinergic receptors in the modulation of cytokine production.
Regulation (modulation) of Gene_expression (production) of cytokine associated with cytokine
10) Confidence 0.00 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2096759 Disease Relevance 0.20 Pain Relevance 0.30
This review focuses on several cellular systems where purinergic modulation of cytokine production has been demonstrated and mechanistic explanations have been sought.
Regulation (modulation) of Gene_expression (production) of cytokine associated with cytokine
11) Confidence 0.00 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.99 Pain Relevance 0.54
We also previously (13, 14) developed bioassays to determine whether Perna modulated either or both antibody and inflammatory cytokine production.
Spec (whether) Regulation (modulated) of Gene_expression (production) of cytokine associated with inflammation and cytokine
12) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1899520 Disease Relevance 0.50 Pain Relevance 0.32
Prior to examining if curcumin and resveratrol have an effect on cytokine production by adipocytes, we wish to confirm that these natural products are not harmful to this cell type.
Spec (examining) Regulation (effect) of Gene_expression (production) of cytokine in adipocytes associated with obesity and cytokine
13) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 0.56 Pain Relevance 0.10
B signaling, cytokine expression analyses should include a quantitative assessment of secreted cytokines to identify possible post-transcriptional control of cytokine expression.
Spec (possible) Regulation (control) of Gene_expression (expression) of cytokine associated with cytokine
14) Confidence 0.00 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 0.40 Pain Relevance 0.31

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