INT209581

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 7.86
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) DNA binding (Twist1) cytoplasm (VEGFA)
extracellular space (VEGFA) extracellular region (VEGFA) growth (VEGFA)
Twist1 (Mus musculus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 106 85.92 High High
Inflammatory stimuli 1 47.68 Quite Low
metalloproteinase 12 46.92 Quite Low
Inflammation 63 35.76 Quite Low
ischemia 2 35.36 Quite Low
alcohol 2 12.40 Low Low
cINOD 34 5.00 Very Low Very Low Very Low
cytokine 26 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 436 100.00 Very High Very High Very High
Necrosis 20 99.64 Very High Very High Very High
Fever 82 97.08 Very High Very High Very High
Age-related Macular Degeneration 87 92.96 High High
Bladder Cancer 8 90.08 High High
Ocular Hypertension 27 88.72 High High
Carcinoma 10 87.52 High High
Hypoxia 7 85.00 Quite High
Cv General 2 Under Development 6 81.56 Quite High
Apoptosis 370 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, it was demonstrated that PDT induced vascular endothelial growth factor expression (VEGF) and this increase was attenuated by treating mice with NS-398, meaning that COX-2 might play a role also in angiogenesis.
PDT Positive_regulation (induced) of Gene_expression (expression) of VEGF
1) Confidence 0.06 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.09 Pain Relevance 0.08
Use of an antiangiogenic factor can counteract the PDT induced over-expression of VEGF and reduce its adverse effects.
PDT Positive_regulation (induced) of Gene_expression (over) of VEGF
2) Confidence 0.05 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1904176 Disease Relevance 0.80 Pain Relevance 0
Use of an antiangiogenic factor can counteract the PDT induced over-expression of VEGF and reduce its adverse effects.
PDT Positive_regulation (induced) of Gene_expression (expression) of VEGF
3) Confidence 0.05 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1904176 Disease Relevance 0.80 Pain Relevance 0
Here, it was demonstrated that PDT induced vascular endothelial growth factor expression (VEGF) and this increase was attenuated by treating mice with NS-398, meaning that COX-2 might play a role also in angiogenesis.
PDT Positive_regulation (induced) of Gene_expression (expression) of vascular endothelial growth factor
4) Confidence 0.05 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.09 Pain Relevance 0.08
In the contrary, long drug light interval hypericin-PDT induced the expression of angiogenic proteins, such as vascular endothelial growth factor (VEGF), tumor necrosis growth factor-?
hypericin-PDT Positive_regulation (induced) of Gene_expression (expression) of vascular endothelial growth factor associated with necrosis and cancer
5) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.77 Pain Relevance 0
In the contrary, long drug light interval hypericin-PDT induced the expression of angiogenic proteins, such as vascular endothelial growth factor (VEGF), tumor necrosis growth factor-?
hypericin-PDT Positive_regulation (induced) of Gene_expression (expression) of VEGF associated with necrosis and cancer
6) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.77 Pain Relevance 0
Studies have also revealed that PDT could cause choroidal hypoperfusion and upregulate the production of vascular endothelial growth factor (VEGF).
PDT Positive_regulation (upregulate) of Gene_expression (production) of VEGF
7) Confidence 0.01 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635983 Disease Relevance 0.54 Pain Relevance 0

General Comments

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