INT209594

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.06
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN3B)
Anatomy Link Frequency
brain 4
synapses 2
GRIN3B (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 89 100.00 Very High Very High Very High
nMDA receptor 73 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
long-term potentiation 70 99.56 Very High Very High Very High
cytokine 10 92.68 High High
Dorsal horn neuron 13 92.20 High High
Spinal cord 4 91.40 High High
Hippocampus 55 82.88 Quite High
adenocard 3 79.60 Quite High
dorsal root ganglion 3 79.60 Quite High
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 176 93.52 High High
Stress 164 87.56 High High
Nociception 10 79.76 Quite High
Ganglion Cysts 3 79.60 Quite High
Injury 69 74.20 Quite High
Pain 49 68.00 Quite High
Frailty 12 67.64 Quite High
Drug Induced Neurotoxicity 8 57.44 Quite High
Traumatic Stress Disorders 10 50.00 Quite Low
INFLAMMATION 7 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A majority of synapses that experience LTP involve an increase in calcium which is mediated through activation of the NMDA receptor.
Positive_regulation (mediated) of Positive_regulation (activation) of NMDA receptor in synapses associated with nmda receptor and long-term potentiation
1) Confidence 0.05 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0.39
The NMDA receptor is involved in the normal processes of memory encoding while overstimulation of the NMDA receptor leads to the formation of strongly ingrained emotional memories via excessive mobilization of free cytosolic Ca2+.
Positive_regulation (leads) of Positive_regulation (overstimulation) of NMDA receptor associated with nmda receptor
2) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.69 Pain Relevance 0.34
Soluble guanylate cyclase represents the most important NO receptor in the brain (Dawson VL and Dawson TM 1995), with its activation by NO following glutamate-mediated activation of the NMDA receptor leading to an increase in the second messenger – cyclic guanosine monophosphate (cGMP) (Fedele et al 2001).
Positive_regulation (activation) of Positive_regulation (activation) of NMDA receptor in brain associated with glutamate and nmda receptor
3) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0 Pain Relevance 0.22
However, in other areas of the brain, there is no requirement of SP for the induction of NMDA receptor dependent LTP [39].
Neg (no) Positive_regulation (requirement) of Positive_regulation (induction) of NMDA receptor in brain associated with nmda receptor, long-term potentiation and substance p
4) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.37 Pain Relevance 1.22

General Comments

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