INT209602

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.25
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd22) plasma membrane (Cd22)
Anatomy Link Frequency
B cell 6
marginal zone 2
Cd22 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 98.88 Very High Very High Very High
abdominal pain 4 87.32 High High
vincristine 4 77.60 Quite High
Pain 2 65.88 Quite High
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 113 99.98 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.92 Very High Very High Very High
Hyperplasia 4 97.24 Very High Very High Very High
Splenomegaly 8 96.00 Very High Very High Very High
Fever 7 88.12 High High
Lymphadenopathy 10 87.72 High High
Abdominal Pain 4 87.32 High High
B-cell Lymphoma 2 86.88 High High
Pleural Effusion 2 83.68 Quite High
Follicular Lymphoma 25 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Positive_regulation (include) of Neg (negative) Gene_expression (negative) of CD22 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
1) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.16 Pain Relevance 0
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, CD10(dim), surface IgG, HLA-DR and CD43, but negative for CD5, CD34, and tdT.
Positive_regulation (population) of Neg (negative) Gene_expression (expressing) of CD22 in B cell
2) Confidence 0.07 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.05 Pain Relevance 0.07
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, HLA-DR and kappa, but negative for CD5, CD10, CD23, and CD34, and tdT.
Positive_regulation (population) of Neg (negative) Gene_expression (expressing) of CD22 in B cell
3) Confidence 0.07 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.04 Pain Relevance 0.19
Anne Krug found that PDCs synergistically enhance activation and cytokine production of human peripheral blood B cells that were stimulated by B-cell receptor ligation (anti-Ig) and a microbial molecular (CpG) [36].
Positive_regulation (stimulated) of Gene_expression (ligation) of B-cell receptor in B-cell associated with cytokine
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.08

General Comments

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