INT20964

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 96
Total Number 98
Disease Relevance 23.54
Pain Relevance 58.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
CHO 6
MDM 3
keratinocytes 3
prefrontal 3
oocytes 3
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 366 100.00 Very High Very High Very High
Kappa opioid receptor 310 100.00 Very High Very High Very High
agonist 139 100.00 Very High Very High Very High
Opioid 116 100.00 Very High Very High Very High
Dynorphin 70 100.00 Very High Very High Very High
mu opioid receptor 55 100.00 Very High Very High Very High
opiate 24 100.00 Very High Very High Very High
narcan 22 100.00 Very High Very High Very High
adenocard 3 100.00 Very High Very High Very High
medulla 22 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dystonia 12 99.98 Very High Very High Very High
Bordatella Infection 23 99.80 Very High Very High Very High
Rheumatoid Arthritis 91 99.44 Very High Very High Very High
Urological Neuroanatomy 4 99.40 Very High Very High Very High
Pain 48 99.08 Very High Very High Very High
Targeted Disruption 4 98.68 Very High Very High Very High
Cv General 4 Under Development 2 98.28 Very High Very High Very High
Stress 1 98.08 Very High Very High Very High
Thymoma 1 97.84 Very High Very High Very High
Schizophrenia 9 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The kappa-opioid receptor mRNA was expressed on four cell types, namely, T and B cells, macrophages, and natural killer (NK) cells in RA patients; however, it was expressed only on the T and B cells and macrophages (and not on NK cells) in the healthy volunteers.
Gene_expression (expressed) of kappa-opioid receptor mRNA in B cells associated with rheumatoid arthritis and kappa opioid receptor
1) Confidence 0.78 Published 2000 Journal Rheumatol. Int. Section Abstract Doc Link 10776687 Disease Relevance 1.39 Pain Relevance 1.14
Expression of kappa-opioid receptor mRNA in human peripheral blood lymphocytes and the relationship between its expression and the inflammatory changes in rheumatoid arthritis.
Gene_expression (Expression) of kappa-opioid receptor mRNA in blood associated with inflammation, rheumatoid arthritis and kappa opioid receptor
2) Confidence 0.78 Published 2000 Journal Rheumatol. Int. Section Title Doc Link 10776687 Disease Relevance 1.01 Pain Relevance 0.77
Our findings suggest that the levels of expression of kappa-opioid receptor mRNA were decreased in RA patients in comparison with those in healthy volunteers; and that they were significantly related to the inflammatory activity or chronic pain in the RA patients.
Gene_expression (expression) of kappa-opioid receptor mRNA associated with inflammation, lasting pain, rheumatoid arthritis and kappa opioid receptor
3) Confidence 0.78 Published 2000 Journal Rheumatol. Int. Section Abstract Doc Link 10776687 Disease Relevance 1.37 Pain Relevance 1.20
The expression of the kappa-opioid receptor on human peripheral blood cells (in rheumatoid arthritis cases and normal volunteers) was examined using reverse transcriptase polymerase chain reaction (RT-PCR), and the relationship between its expression and the inflammatory activity or chronic pain in patients with rheumatoid arthritis (RA) was determined.
Spec (examined) Gene_expression (expression) of kappa-opioid receptor in blood cells associated with inflammation, lasting pain, rheumatoid arthritis and kappa opioid receptor
4) Confidence 0.78 Published 2000 Journal Rheumatol. Int. Section Abstract Doc Link 10776687 Disease Relevance 0.79 Pain Relevance 0.56
Regarding the relationship between the expression of kappa-opioid receptor mRNA and the symptoms in RA patients, it was noted that the expression of the receptor mRNA was significantly decreased in RA patients in whom erythrocyte sedimentation rate (ESR), Lansbury index, and visual analogue pain scores were high.
Gene_expression (expression) of kappa-opioid receptor mRNA in erythrocyte associated with pain score, rheumatoid arthritis and kappa opioid receptor
5) Confidence 0.78 Published 2000 Journal Rheumatol. Int. Section Abstract Doc Link 10776687 Disease Relevance 1.24 Pain Relevance 0.94
Also, expression of KOR mRNA and binding activity with a fluorescence-labeled KOR ligand supported the existence of KOR on MDM.
Gene_expression (expression) of KOR mRNA in MDM associated with kappa opioid receptor
6) Confidence 0.77 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11245971 Disease Relevance 0.86 Pain Relevance 0.58
Consistent with the results from skin biopsy, we observed enhanced expression of MOR, DOR and KOR in the cultured keratinocytes and fibroblasts derived from hypertrophic scars in comparison with those derived from normal skin.
Gene_expression (expression) of KOR in fibroblasts
7) Confidence 0.75 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0
CONCLUSIONS: Our results demonstrate that expression of three types of ORs, MOR, DOR and KOR, was markedly upregulated in human hypertrophic scars, suggesting a possible link between upregulated ORs and local cacaesthesia in hypertrophic scars.


Gene_expression (expression) of KOR
8) Confidence 0.75 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0
Real-time PCR indicated that the expression of MOR, DOR and KOR in hypertrophic scars was enhanced in comparison with normal skin.
Gene_expression (expression) of KOR in skin
9) Confidence 0.75 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.07 Pain Relevance 0
In CHO cells expressing kappa-opioid receptors (CHO/KOR), TCAs, but not amoxapine, exhibited higher receptor affinity and more potent stimulation of [(35)S]GTPgammaS binding than in CHO/DOR and effectively inhibited cyclic AMP accumulation.
Gene_expression (expressing) of KOR in CHO associated with kappa opioid receptor and tricyclic antidepressant
10) Confidence 0.75 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19828880 Disease Relevance 0.18 Pain Relevance 1.06
The present study further demonstrates that the KOR of lymphocytes are activated in the presence of extracellular morphine or U50,488H, a KOR selective agonist, and the activation causes an increase in the expression of KOR mRNA, as determined by a quantitative competitive Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) procedure.
Gene_expression (expression) of KOR mRNA in lymphocytes associated with agonist, kappa opioid receptor and morphine
11) Confidence 0.73 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11562065 Disease Relevance 0 Pain Relevance 1.05
We have previously shown that classical brain-like kappa opioid receptors (KOR) are constitutively expressed in lymphocytic cells. including human CEM x174 T-B hybrid cells, Jurkat -T4 cells, human peripheral blood mononuclear cells (PBMC), human CD4+ cells and monkey PBMC (Biochem.
Gene_expression (expressed) of KOR in brain associated with kappa opioid receptor
12) Confidence 0.73 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11562065 Disease Relevance 0 Pain Relevance 0.48
The expression of the cloned kappa-opioid receptor in the spinal cord dorsal horn was not associated with processes immunoreactive for serotonin.
Gene_expression (expression) of kappa-opioid receptor in spinal cord dorsal horn associated with dorsal horn, kappa opioid receptor, serotonin and spinal cord
13) Confidence 0.71 Published 1999 Journal Neuroscience Section Abstract Doc Link 10188949 Disease Relevance 0.07 Pain Relevance 1.37
In addition, cloned kappa-opioid receptor immunoreactivity was expressed in some cell profiles immunoreactive for GABA.
Gene_expression (expressed) of kappa-opioid receptor associated with gaba and kappa opioid receptor
14) Confidence 0.71 Published 1999 Journal Neuroscience Section Abstract Doc Link 10188949 Disease Relevance 0.07 Pain Relevance 1.36
Serotonergic and GABAergic neurons in the medial rostral ventral medulla express kappa-opioid receptor immunoreactivity.
Gene_expression (express) of kappa-opioid receptor in GABAergic neurons associated with medulla, gabaergic and kappa opioid receptor
15) Confidence 0.71 Published 1999 Journal Neuroscience Section Title Doc Link 10188949 Disease Relevance 0.09 Pain Relevance 1.08
Second, we established the cell lines expressing the cloned mu, delta, or kappa receptor and elucidated the pharmacological properties, that is, binding affinity and agonistic activity of several opioid agonists.
Gene_expression (expressing) of kappa receptor associated with mu agonist
16) Confidence 0.69 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 14745129 Disease Relevance 0.12 Pain Relevance 0.51
The presence of the kappa-opioid receptor in granulosa cells, obtained from follicles of varying sizes was demonstrated.
Gene_expression (presence) of kappa-opioid receptor in follicles associated with kappa opioid receptor
17) Confidence 0.69 Published 1997 Journal Cytobios Section Abstract Doc Link 9693886 Disease Relevance 0 Pain Relevance 0.30
The monoclonal anti-kappa-opioid receptor antibody was used to reveal the expression of kappa-opioid receptor.
Gene_expression (expression) of kappa-opioid receptor associated with kappa opioid receptor
18) Confidence 0.69 Published 1997 Journal Cytobios Section Abstract Doc Link 9693886 Disease Relevance 0 Pain Relevance 0.31
Bremazocine and other benzomorphan analogs were synthesized in an effort to produce opiates with greater kappa-opioid receptor selectivity and with minimal morphine-like side effects.
Gene_expression (produce) of kappa-opioid receptor associated with kappa opioid receptor, opiate and morphine
19) Confidence 0.68 Published 2005 Journal CNS Drug Rev Section Abstract Doc Link 16007240 Disease Relevance 0.18 Pain Relevance 1.26
RT-PCR was performed on the peripheral blood cells obtained from 37 patients with RA and 13 healthy volunteers. kappa-Opioid receptor mRNA expression was exhibited on the blood cells of 37% of RA patients (14/ 37) and 54% of healthy volunteers (7/13) , and the levels of expression were lower in the RA patients than in the healthy volunteers.
Gene_expression (expression) of kappa-Opioid receptor mRNA in blood cells associated with rheumatoid arthritis and opioid receptor
20) Confidence 0.67 Published 2000 Journal Rheumatol. Int. Section Abstract Doc Link 10776687 Disease Relevance 1.11 Pain Relevance 0.83

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