INT209641

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
epithelial cells 1
AR (Homo sapiens)
PCa (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Vanilloid receptor-like 3 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 83 100.00 Very High Very High Very High
Disease 7 73.52 Quite High
Cancer 25 70.08 Quite High
Metastasis 5 68.64 Quite High
Recurrence 1 65.40 Quite High
Apoptosis 5 49.52 Quite Low
Genetic Translocation 1 46.40 Quite Low
Repression 7 5.00 Very Low Very Low Very Low
Williams-beuren Syndrome 2 5.00 Very Low Very Low Very Low
Disease Progression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, specific expression in mouse prostate epithelial cells of an AR transgene containing a gain-of-function mutation (with increased basal activity and response to coregulators), resulted in PCa development in 100% of the animals [10] proving that aberrant AR signaling was sufficient to cause PCa and that under certain conditions the AR acts as an oncogene.
AR Positive_regulation (cause) of PCa in epithelial cells associated with prostate cancer
1) Confidence 0.06 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 1.17 Pain Relevance 0

General Comments

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