INT20966

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 24.38
Pain Relevance 15.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton (Arc)
cytoskeleton organization (Arc) cytoplasm (Arc)
Anatomy Link Frequency
neurons 10
brain 2
lenses 2
dorsal horn 2
hypothalamus 2
Arc (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 180 99.98 Very High Very High Very High
Nerve growth factor 2 99.98 Very High Very High Very High
Morphine 73 99.78 Very High Very High Very High
spinal dorsal horn 20 99.68 Very High Very High Very High
Dorsal horn neuron 60 99.56 Very High Very High Very High
intrathecal 100 99.46 Very High Very High Very High
Dorsal horn 123 99.20 Very High Very High Very High
analgesia 7 99.20 Very High Very High Very High
Hippocampus 62 99.08 Very High Very High Very High
opioid receptor 62 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 1838 100.00 Very High Very High Very High
Cataract 96 100.00 Very High Very High Very High
Urological Neuroanatomy 12 100.00 Very High Very High Very High
Nociception 412 99.74 Very High Very High Very High
Pain 280 97.64 Very High Very High Very High
Stress 25 97.24 Very High Very High Very High
Reprotox - General 2 1 97.08 Very High Very High Very High
Targeted Disruption 350 91.12 High High
Inflammatory Pain 41 91.08 High High
Low Back Pain 20 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was accompanied by a corresponding increase in Arc protein level.
Positive_regulation (increase) of Arc protein associated with aids-related complex
1) Confidence 0.70 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.89 Pain Relevance 1.28
They also demonstrate that Arc is induced in the brain in vivo after morphine administration and thus may play a role in neuroadaptations produced by the drug.
Positive_regulation (induced) of Arc in brain associated with aids-related complex and morphine
2) Confidence 0.70 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.75 Pain Relevance 1.05
An acute administration of morphine produced a marked increase in Arc mRNA and protein level in the mouse striatum/nucleus accumbens complex.
Positive_regulation (increase) of Arc mRNA in nucleus accumbens associated with nucleus accumbens, aids-related complex and morphine
3) Confidence 0.70 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.85 Pain Relevance 1.11
However, in the present study a significant increase in the number of Arc/Arg3.1 mRNA expressing neurons could not be confirmed after intrathecal injection of BDNF and NBQX together.
Positive_regulation (increase) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex, bdmf and intrathecal
4) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.31 Pain Relevance 0.92
Several types of nociceptive stimuli applied to the hind paw induced Arc/Arg3.1 mRNA expressing neurons on the ipsilateral side (Fig. 2) but not on the contralateral side of the lumbar superficial dorsal horn.
Positive_regulation (induced) of Arc/Arg3.1 mRNA in neurons associated with nociception, aids-related complex and dorsal horn
5) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.84 Pain Relevance 0.27
Arc/Arg3.1 mRNA and protein were induced in the superficial dorsal horn in the acute phases of all pain models that we tested, i.e. after nociceptive stimulation with capsaicin, CFA, formalin and mustard oil.
Positive_regulation (induced) of Arc/Arg3.1 mRNA in dorsal horn associated with nociception, pain, qutenza, aids-related complex and dorsal horn
6) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.57 Pain Relevance 0.77
Taken together, our findings are in line with the idea that release of glutamate and/or BDNF from activated nociceptive fibers are at least partly responsible for Arc/Arg3.1 induction in the spinal dorsal horn.
Positive_regulation (induction) of Arc/Arg3.1 in dorsal horn associated with nociception, glutamate, aids-related complex, spinal dorsal horn and bdmf
7) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.33 Pain Relevance 0.80
In Neuro2A MOR1A cells, acute, but not prolonged, morphine treatment elevated Arc mRNA level by activation of mu-opioid receptor.
Positive_regulation (elevated) of Arc mRNA associated with aids-related complex, opioid receptor and morphine
8) Confidence 0.50 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.90 Pain Relevance 1.30
This pubertal increase in kisspeptin would normally initiate increased GnRH release and thereby lead to activation of the gonads; however, in WT mice, this increase in ARC Kiss1 mRNA is not appreciated.
Positive_regulation (increase) of ARC in gonads associated with aids-related complex
9) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.62 Pain Relevance 0
Increases in ARC Kiss1 mRNA was not found in our study in intact mice between P10 and P30 and may represent differences in species, time points studied, or methodology in qRT-PCR expression normalization; e.g. in our protocol we controlled for developmental changes in ARC size.
Positive_regulation (Increases) of ARC associated with aids-related complex
10) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.63 Pain Relevance 0
Arc is an immediate early gene induced by neuronal activity (for review, see Tzingounis & Nicoll 2006).
Positive_regulation (induced) of Arc in neuronal associated with aids-related complex
11) Confidence 0.43 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.71 Pain Relevance 0.06
Earlier studies demonstrated Arc induction in discrete brain regions by several psychoactive substances, including drugs of abuse.
Positive_regulation (induction) of Arc in brain associated with aids-related complex
12) Confidence 0.41 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.55 Pain Relevance 0.56
We found that intrathecal injection of NMDA or BDNF induced Arc/Arg3.1 mRNA in spinal dorsal horn neurons.
Positive_regulation (induced) of Arc/Arg3.1 mRNA in spinal associated with aids-related complex, dorsal horn neuron, bdmf and intrathecal
13) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.07 Pain Relevance 0.86
The number of neurons expressing the neuronal activation marker c-Fos or Arc/Arg3.1 mRNA was counted in separate sections treated with IHC or ISH, respectively. c-Fos labeled neurons outnumbered Arc/Arg3.1 mRNA labeled neurons (Fig. 3A), except after 2 hrs mustard oil stimulation when about equal number of neurons were labeled.
Positive_regulation (activation) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex
14) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.99 Pain Relevance 0.20
We found a high percentage of Arc/Arg3.1 expressing neurons (68%) to contain preproenkephalin, while percentages of colocalization with other markers were less prominent (19% for NK-1; 8.5% for PKC-?
Positive_regulation (percentage) of Arc/Arg3.1 in neurons associated with aids-related complex
15) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.43 Pain Relevance 0.49
The immunoreactive density of the fiber staining for kisspeptin increased qualitatively in the ARC in both female and male WT mice during development, peaking at P45.
Positive_regulation (increased) of ARC associated with aids-related complex
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.70 Pain Relevance 0
Our data show that Arc/Arg3.1, which is critically involved in consolidating long term structural changes in the forebrain, is preferentially induced in spinal enkephalinergic neurons after nociceptive stimulation.
Positive_regulation (induced) of Arc/Arg3.1 in neurons associated with nociception and aids-related complex
17) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.74 Pain Relevance 0.63
It was found that 50% MO induced significantly higher numbers of Arc/Arg3.1 mRNA positive neurons that 10% mustard oil (Fig. 4A).
Positive_regulation (numbers) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex
18) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.00 Pain Relevance 0.22
In this study we have used in situ hybridization (ISH) and immunohistochemistry (IHC) to show that nociceptive stimulation induced Arc/Arg3.1 mRNA and protein in the superficial dorsal horn of the spinal cord.
Positive_regulation (induced) of Arc/Arg3.1 mRNA in spinal cord associated with nociception, aids-related complex, dorsal horn and spinal cord
19) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.54 Pain Relevance 0.40
All of these in vivo effects were observed at a relatively early time point (1 to 2 h after injection) and were connected with the induction of a group of immediate early gene (IEG) transcription factors and neuroplasticity-related genes like Fos, Arc, Npas4 and Homer1.
Positive_regulation (induction) of Arc associated with aids-related complex
20) Confidence 0.36 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.10 Pain Relevance 0.19

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