INT209679

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.88
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Anatomy Link Frequency
neurons 2
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 51 96.88 Very High Very High Very High
Central grey 93 96.72 Very High Very High Very High
analgesia 23 70.84 Quite High
Pain 20 70.28 Quite High
Morphine 79 63.76 Quite High
Antihyperalgesic 1 62.56 Quite High
Potency 7 57.96 Quite High
antinociception 9 54.24 Quite High
mu opioid receptor 15 46.00 Quite Low
Antinociceptive 5 38.24 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 95 96.72 Very High Very High Very High
Cancer 62 95.32 Very High Very High Very High
Malignant Neoplastic Disease 10 93.88 High High
Reprotox - General 1 54 87.84 High High
Pain 30 70.28 Quite High
Prostate Cancer 83 5.00 Very Low Very Low Very Low
Repression 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Metastasis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AR location analysis discloses ligand-independent, AR-dependent gene regulation
Neg (independent) Positive_regulation (independent) of Neg (independent) Regulation (regulation) of AR-dependent
1) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0 Pain Relevance 0
The regulation of arginase expression following androgen stimulation was dependent on the androgen receptor (AR), as a siRNA treatment targeting the AR inhibited both ARG1 and ARG2 overexpression.
Positive_regulation (dependent) of Regulation (regulation) of AR
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 1.00 Pain Relevance 0
males had a significantly greater number of AR immunoreactive neurons localized
Positive_regulation (had) of Regulation (number) of AR in neurons
3) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.88 Pain Relevance 0.96

General Comments

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