INT20976

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Context Info
Confidence 0.46
First Reported 1990
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 39
Total Number 42
Disease Relevance 5.40
Pain Relevance 20.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CHO 4
plasma 1
gray matter 1
brain 1
platelet 1
CRYGS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 44 100.00 Very High Very High Very High
agonist 153 99.82 Very High Very High Very High
Dynorphin 14 99.80 Very High Very High Very High
Opioid 80 99.74 Very High Very High Very High
gABA 33 99.60 Very High Very High Very High
Sumatriptan 12 99.58 Very High Very High Very High
opioid receptor 24 99.56 Very High Very High Very High
Kappa opioid receptor 30 99.46 Very High Very High Very High
Enkephalin 18 99.00 Very High Very High Very High
orphanin 36 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 4 99.86 Very High Very High Very High
Epilepsy 14 99.60 Very High Very High Very High
Bordatella Infection 24 98.56 Very High Very High Very High
Convulsion 2 98.44 Very High Very High Very High
Cancer 2 97.98 Very High Very High Very High
Sclerosis 6 97.52 Very High Very High Very High
Vibrio Infection 7 91.28 High High
Hyperalgesia 3 84.72 Quite High
Glioma 13 79.08 Quite High
Respiratory Tract Infection 1 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The optimal conditions for [35S]GTPgammaS binding to human brain homogenates were established in postmortem samples of prefrontal cortex.
GTPgammaS Binding (binding) of in cortex
1) Confidence 0.46 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.12
Characterization of receptor-mediated [35S]GTPgammaS binding to cortical membranes from postmortem human brain.
GTPgammaS Binding (binding) of in brain
2) Confidence 0.34 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.23
The G(i)/G(o)-protein alkylating agent N-ethylmaleimide decreased basal [35S]GTPgammaS binding in a concentration-dependent manner and inhibited the stimulation induced by the different agonists.
GTPgammaS Binding (binding) of associated with agonist
3) Confidence 0.34 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.40
In cortical sections, [35S]GTPgammaS binding to gray matter was stimulated by the agonist UK14304.
GTPgammaS Binding (binding) of in gray matter associated with agonist
4) Confidence 0.34 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.38
In conditions of 50 microM GDP and 100 mM NaCl, UK14304 increased the apparent affinity of the specific [35S]GTPgammaS binding without changing the apparent density.
GTPgammaS Binding (binding) of
5) Confidence 0.30 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.33
The influence of protein content, incubation time, GDP, Mg(2+), and NaCl concentrations on the [35S]GTPgammaS binding were assessed in the absence and presence of the alpha(2)-adrenoceptor agonist UK14304 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine).
GTPgammaS Binding (binding) of associated with agonist
6) Confidence 0.30 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.24
The stimulation of [35S]GTPgammaS binding by the mu-opioid receptor agonist DAMGO or the alpha2-adrenoceptor agonist UK14304 was used as a functional measure of the status of the receptor-G-protein coupling. [35S]GTPgammaS binding basal values were similar in opioid addicts (819+/-83 fmol mg-1 of protein) and controls (918+/-106 fmol mg(-1) of protein).
GTPgammaS Binding (binding) of associated with agonist, opioid receptor and opioid
7) Confidence 0.07 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889534 Disease Relevance 0.09 Pain Relevance 0.93
The rank order of potencies of opioid ligands tested in stimulating [35S]GTPgammaS binding was dynorphin A 1-17 > (+/-)-ethylketocyclazocine > beta-funaltrexamine, (-)-U50,488H, tifluadom > nalorphine > pentazocine, nalbuphine > buprenorphine.
GTPgammaS Binding (binding) of associated with fortral, dynorphin, nalbuphine, opioid and buprenorphine
8) Confidence 0.06 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262330 Disease Relevance 0.17 Pain Relevance 1.06
Comparison of the binding K(i) in competitively inhibiting [(125)I]IOXY binding to the functional K(i) for delta antagonists [Ki (IOXY)/Ki (GTP-gamma-S)] shows that antagonists might antagonize agonist-evoked neurochemical effects with equal magnitude while occupying different proportions of target receptors.
GTP-gamma-S Spec (might) Binding (binding) of associated with antagonist and agonist
9) Confidence 0.06 Published 2001 Journal Synapse Section Abstract Doc Link 11309842 Disease Relevance 0.08 Pain Relevance 0.50
The rank order of potencies of adrenergic ligands tested in stimulating [3S]GTPgammaS binding and inhibiting forskolin-stimulated c-AMP accumulation was UK 14304> Guanabenz acetate> Oxymetazoline hydrochloride> B-HT 920 dihydrochloride> p-Aminoclonidine hydrochloride> Clonidine hydrochloride.
GTPgammaS Binding (binding) of associated with clonidine
10) Confidence 0.06 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.21
To assess the activity of G-proteins and their coupling to receptors after chronic opioid abuse, [35S]GTPgammaS binding was quantified in postmortem prefrontal cortices of 15 opioid-dependent subjects and 15 matched controls.
GTPgammaS Binding (binding) of in prefrontal associated with opioid
11) Confidence 0.06 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889534 Disease Relevance 0.10 Pain Relevance 0.81
Both peptide and nonpeptide agonists maximally stimulated [35S]GTPgammaS binding.
GTPgammaS Binding (binding) of associated with agonist
12) Confidence 0.05 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918595 Disease Relevance 0.25 Pain Relevance 0.37
The stimulation of [35S]GTPgammaS binding was blocked by pretreatment of cells with pertussis toxin.
GTPgammaS Binding (binding) of associated with bordatella infection
13) Confidence 0.05 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918595 Disease Relevance 0.25 Pain Relevance 0.37
In addition, (-)tifluadom, the less potent isomer of tifluadom, which is also a gamma-aminobutyric acidA receptor agonist, stimulated [35S]GTPgammaS binding.
GTPgammaS Binding (binding) of associated with agonist
14) Confidence 0.05 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918595 Disease Relevance 0.15 Pain Relevance 0.55
Alpha2-adrenergic agonist modulation of [35S]GTPgammaS binding to guanine-nucleotide-binding-proteins in human platelet membranes.
GTPgammaS Binding (binding) of in platelet associated with agonist
15) Confidence 0.05 Published 1999 Journal Life Sci. Section Title Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.19
The presence of 100 mM Na+ was necessary to produce the maximal signal-to-background ratio. (-)U50,488H-induced increase in [35S]GTPgammaS binding was time- and tissue concentration-dependent. (-)U50,488H increased [35S]GTPgammaS binding in a dose-dependent manner with an EC50 of 3.1 nM. (+)-U50,488H had no effect, which indicates that this effect is stereospecific.
GTPgammaS Binding (binding) of
16) Confidence 0.05 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262330 Disease Relevance 0.20 Pain Relevance 0.24
The presence of GDP and Mg++ was essential for the kappa agonist (-)-U50,488H-induced increase in [35S]GTPgammaS binding to be observed and the optimal concentration was 3 microM and 5 mM, respectively.
GTPgammaS Binding (binding) of associated with agonist
17) Confidence 0.05 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262330 Disease Relevance 0.08 Pain Relevance 0.25
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
GTPgammaS Spec (determination) Binding (binding) of associated with agonist, kappa opioid receptor and enkephalin
18) Confidence 0.05 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9262330 Disease Relevance 0.09 Pain Relevance 0.35
These results indicate that enhancement of [35S]GTPgammaS binding by (-)-U50,488H is a kappa receptor-mediated event.
GTPgammaS Binding (binding) of
19) Confidence 0.05 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262330 Disease Relevance 0.24 Pain Relevance 0.48
In this study, the effects of activation of the human kappa receptor by agonists on [35S]GTPgammaS binding to CHO cell membranes were examined.
GTPgammaS Binding (binding) of in CHO associated with agonist
20) Confidence 0.05 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262330 Disease Relevance 0.09 Pain Relevance 0.24

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