INT209783

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SLC15A4)
Anatomy Link Frequency
macrophage 1
liver 1
fibroblast 1
SLC15A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 2 99.12 Very High Very High Very High
cytokine 36 85.84 High High
sodium channel 10 73.92 Quite High
alcohol 1 66.44 Quite High
Inflammatory response 2 64.40 Quite High
metalloproteinase 6 50.00 Quite Low
Calcium channel 2 26.40 Quite Low
Inflammation 14 5.00 Very Low Very Low Very Low
anticonvulsant 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 18 100.00 Very High Very High Very High
Splenomegaly 3 99.92 Very High Very High Very High
Fibrosis 5 99.12 Very High Very High Very High
Hemorrhage 12 82.64 Quite High
Esophageal Varices 4 81.20 Quite High
Liver Disease 2 73.88 Quite High
Alcohol Addiction 1 66.68 Quite High
INFLAMMATION 16 64.40 Quite High
Multiple Sclerosis 2 61.36 Quite High
Gingival Overgrowth 20 56.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patient had a duplex ultrasound (DUS) examination of the abdomen that revealed the findings of PHT, splenomegaly, normal liver and no ascites.
PHT Neg (no) Binding (findings) of in liver associated with pressure and volume under development and splenomegaly
1) Confidence 0.04 Published 2007 Journal BMC Surg Section Body Doc Link PMC1905910 Disease Relevance 0.97 Pain Relevance 0.03
How PHT and HPPH impact monocyte/macrophage-fibroblast interactions and MMP production requires further study.
PHT Binding (interactions) of in fibroblast
2) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.18 Pain Relevance 0.11
Given the presence of significant numbers of macrophages in gingival tissues and the correlation between the quality of plaque control and fibrosis, our data reveals a mechanism whereby both PHT and its metabolite, HPPH dysregulate macrophage function.
PHT Binding (metabolite) of in macrophage associated with fibrosis
3) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.10 Pain Relevance 0.15

General Comments

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