INT20982

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Context Info
Confidence 0.28
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 7.27
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINB1) cytoplasm (SERPINB1)
Anatomy Link Frequency
guard cells 1
face 1
ASK 1
T cell 1
SERPINB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 65 98.92 Very High Very High Very High
Lasting pain 1 98.52 Very High Very High Very High
Pain 3 94.56 High High
Chronic pancreatitis 2 94.24 High High
headache 4 90.36 High High
antagonist 2 89.84 High High
abdominal pain 1 89.56 High High
Enkephalin 3 85.08 High High
Opioid 3 84.96 Quite High
opioid receptor 1 82.72 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 118 99.84 Very High Very High Very High
Pancreatitis 6 99.84 Very High Very High Very High
Vasculitis 13 99.00 Very High Very High Very High
Multiple Sclerosis 69 98.92 Very High Very High Very High
Streptococcal Infections 6 98.24 Very High Very High Very High
Pain 2 98.20 Very High Very High Very High
Infection 6 97.28 Very High Very High Very High
Livedo Reticularis 1 96.36 Very High Very High Very High
Dementia 1 95.84 Very High Very High Very High
Epstein-barr Virus 9 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-EB virus (EA-DR-IgG) was initially elevated on admission and was decreased after that, furthermore anti EBNA was elevated in the late period of his clinical course, which indicated primary infection or secondary alteration of EBV immunity.
Positive_regulation (elevated) of anti EBNA associated with epstein-barr virus and infection
1) Confidence 0.28 Published 1994 Journal Rinsho Ketsueki Section Abstract Doc Link 8065021 Disease Relevance 1.34 Pain Relevance 0.09
The kinetics of the response are similar to those for in vitro T cell responses to antigen rather than via polyclonal activation through lectin or anti-CD3 triggering, suggesting a physiological basis for the phenomenon.
Positive_regulation (activation) of anti-CD3 in T cell
2) Confidence 0.17 Published 1990 Journal Immunopharmacology Section Abstract Doc Link 2161808 Disease Relevance 0 Pain Relevance 0.60
As some serpins also guard cells against the deleterious effects of promiscuous proteolytic activity [23], it is possible that the cytoprotective function is a common feature of intracellular serpin clades and we hypothesize that up-regulation of serpin B1 gene may be protective in MS.
Positive_regulation (regulation) of serpin B1 in guard cells associated with multiple sclerosis
3) Confidence 0.11 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.82 Pain Relevance 0.22
Serology tests showed high frequencies of Anti Nuclear Antibody (ANA) and Anti ds DNA.
Positive_regulation (frequencies) of Anti
4) Confidence 0.05 Published 2009 Journal Afr J Med Med Sci Section Abstract Doc Link 19722426 Disease Relevance 1.17 Pain Relevance 0.09
Fecal excretion of another serum anti-proteinase, alpha2-macroglobulin, is also increased in IBD patients.
Positive_regulation (increased) of serum anti-proteinase associated with inflammatory bowel disease
5) Confidence 0.03 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.04 Pain Relevance 0.16
Anti-streptolysin O (ASO) and anti-streptokinase (ASK) increased and we suspected that C-PAN followed after streptococcal infection.
Positive_regulation (increased) of anti-streptokinase in ASK associated with streptococcal infections and vasculitis
6) Confidence 0.00 Published 1999 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 11126666 Disease Relevance 2.18 Pain Relevance 0.13
About 50% of the patients with chronic pancreatic disease showed increased levels of serum elastase, sometimes even in the face of long lasting pain-free periods, and/or of severe pancreatic impairment.
Positive_regulation (increased) of serum elastase in face associated with pain, lasting pain and pancreatitis
7) Confidence 0.00 Published 1987 Journal Int. J. Pancreatol. Section Abstract Doc Link 2447209 Disease Relevance 0.65 Pain Relevance 0.33

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