INT209849

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.18
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, CD36) transport (CD36) small molecule metabolic process (CD36)
Golgi apparatus (CD36) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
monocytes 2
TNF (Homo sapiens)
CD36 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 219 99.70 Very High Very High Very High
antagonist 3 21.84 Low Low
Inflammation 57 5.00 Very Low Very Low Very Low
rheumatoid arthritis 33 5.00 Very Low Very Low Very Low
cytokine 21 5.00 Very Low Very Low Very Low
aspirin 9 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 99.92 Very High Very High Very High
Necrosis 12 50.00 Quite Low
Cancer 12 50.00 Quite Low
INFLAMMATION 66 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 36 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 33 5.00 Very Low Very Low Very Low
Disease 24 5.00 Very Low Very Low Very Low
Atherosclerosis 21 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since redox signaling is involved in the regulation of CD36 expression in human monocytes [21,22], we analyzed its role in the repression of CD36 membrane expression induced by TNF?
TNF Positive_regulation (induced) of Gene_expression (expression) of CD36 in monocytes associated with repression
1) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.10 Pain Relevance 0
The role of ROS production in the regulation of CD36 expression induced by TNF?
TNF Positive_regulation (induced) of Gene_expression (expression) of CD36
2) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.09 Pain Relevance 0
Furthermore, adalimumab independently increased membrane expression of CD36 by 59% (194.9 ± 42.3 versus 122.8 ± 23.2, p = 0.03) in the presence of TNF?
TNF Positive_regulation (increased) of Gene_expression (expression) of CD36 associated with adalimumab
3) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.25

General Comments

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