INT209849

Context Info Confidence 0.69 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.18 Pain Relevance 0.25

plasma membrane (TNF, CD36) transport (CD36) small molecule metabolic process (CD36) Golgi apparatus (CD36) intracellular (TNF) extracellular matrix organization (TNF)

Anatomy Link Frequency monocytes 2 TNF (Homo sapiens) CD36 (Homo sapiens)

Pain Link Frequency Relevance Heat Adalimumab 219 99.70 antagonist 3 21.84 Inflammation 57 5.00 rheumatoid arthritis 33 5.00 cytokine 21 5.00 aspirin 9 5.00 dexamethasone 6 5.00 Inflammatory response 6 5.00 methotrexate 3 5.00 cINOD 3 5.00

Disease Link Frequency Relevance Heat Repression 6 99.92 Necrosis 12 50.00 Cancer 12 50.00 INFLAMMATION 66 5.00 Increased Venous Pressure Under Development 36 5.00 Rheumatoid Arthritis 33 5.00 Disease 24 5.00 Atherosclerosis 21 5.00 Adhesions 12 5.00 Obesity 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since redox signaling is involved in the regulation of CD36 expression in human monocytes [21,22], we analyzed its role in the repression of CD36 membrane expression induced by TNF?

TNF Positive_regulation (induced) of Gene_expression (expression) of CD36 in monocytes associated with repression

1) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.10 Pain Relevance 0

The role of ROS production in the regulation of CD36 expression induced by TNF?

TNF Positive_regulation (induced) of Gene_expression (expression) of CD36

2) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.09 Pain Relevance 0

Furthermore, adalimumab independently increased membrane expression of CD36 by 59% (194.9 ± 42.3 versus 122.8 ± 23.2, p = 0.03) in the presence of TNF?

TNF Positive_regulation (increased) of Gene_expression (expression) of CD36 associated with adalimumab

3) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.25

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