INT209866

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 27
Total Number 30
Disease Relevance 10.04
Pain Relevance 8.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CD36) transport (CD36) small molecule metabolic process (CD36)
cell adhesion (CD36) Golgi apparatus (CD36) plasma membrane (CD36)
Anatomy Link Frequency
monocytes 12
macrophages 4
mononuclear cells 2
CD36 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 1971 100.00 Very High Very High Very High
aspirin 81 99.84 Very High Very High Very High
Inflammation 535 99.56 Very High Very High Very High
rheumatoid arthritis 506 99.32 Very High Very High Very High
cytokine 199 98.66 Very High Very High Very High
dexamethasone 54 95.64 Very High Very High Very High
chemokine 89 94.08 High High
cINOD 29 93.48 High High
antagonist 33 81.76 Quite High
Inflammatory response 56 70.96 Quite High
Disease Link Frequency Relevance Heat
Repression 54 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 326 99.90 Very High Very High Very High
INFLAMMATION 615 99.56 Very High Very High Very High
Rheumatoid Arthritis 544 99.32 Very High Very High Very High
Necrosis 113 99.12 Very High Very High Very High
Cancer 183 98.94 Very High Very High Very High
Disease 250 98.20 Very High Very High Very High
Atherosclerosis 189 91.16 High High
Apoptosis 12 90.56 High High
Targeted Disruption 3 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since redox signaling is involved in the regulation of CD36 expression in human monocytes [21,22], we analyzed its role in the repression of CD36 membrane expression induced by TNF?
Regulation (regulation) of Gene_expression (expression) of CD36 in monocytes associated with repression
1) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.10 Pain Relevance 0
The phagocytosis of oxidized low density lipoproteins (LDLs) accumulated in the subendothelium by mononuclear cells influences atherosclerosis and depends on CD36 expression.
Regulation (depends) of Gene_expression (expression) of CD36 in mononuclear cells associated with increased venous pressure under development
2) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906797 Disease Relevance 0.87 Pain Relevance 0.34
Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes

In chronic inflammatory diseases, such as rheumatoid arthritis, inflammation acts as an independent cardiovascular risk factor and the use of anti-inflammatory drugs, such as anti-tumor necrosis factor alpha (anti-TNF?)

Regulation (regulate) of Gene_expression (expression) of CD36 in monocytes associated with necrosis, inflammation, cancer, cinod, rheumatoid arthritis, adalimumab and disease
3) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC1906797 Disease Relevance 0.95 Pain Relevance 0.39
Some therapeutic agents used in human pathology for their anti-inflammatory properties appear to modulate expression of CD36 by monocytes/macrophages and dendritic cells: aspirin induces expression of CD36 by human macrophages while dexamethasone induces expression of CD36 by dendritic cells [23,24].
Spec (appear) Regulation (modulate) of Gene_expression (expression) of CD36 in macrophages associated with aspirin, inflammation and dexamethasone
4) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.62 Pain Relevance 0.31
Redox signaling also plays a major role in regulating the expression of CD36.
Regulation (regulating) of Gene_expression (expression) of CD36
5) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.55 Pain Relevance 0.28
Different cytokines essential for the regulation of inflammatory and immune responses modulate the expression of CD36 by macrophages.
Regulation (modulate) of Gene_expression (expression) of CD36 in macrophages associated with inflammation and cytokine
6) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.89 Pain Relevance 0.29
Characterizing the mechanisms involved in this differential regulation of CD36 expression may have implications for the prevention of high cardiovascular mortality observed in chronic inflammatory diseases.


Regulation (regulation) of Gene_expression (expression) of CD36 associated with inflammation and disease
7) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.72 Pain Relevance 0.36
on the regulation of membrane expression of CD36, monocytes were treated with TNF?
Regulation (regulation) of Gene_expression (expression) of CD36 in monocytes
8) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.08
Previous work reported that certain pharmacological agents, whose anti-inflammatory properties are used in human therapy, regulate in vitro CD36 expression.
Regulation (regulate) of Gene_expression (expression) of CD36 associated with inflammation
9) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.23 Pain Relevance 0.28
did not influence membrane expression of CD36 after 6 h of cell culture in comparison to basal conditions (mean ± SD: 91.8 ± 9.2 versus 94.2 ± 11.2, -4%, p = 0.5).
Neg (not) Regulation (influence) of Gene_expression (expression) of CD36
10) Confidence 0.52 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.07
is a transcription factor that plays a key role in inducing membrane expression of CD36 on human monocytes [19], we investigated its implication in the regulation of CD36 expression by TNF?.
Spec (investigated) Regulation (regulation) of Gene_expression (expression) of CD36 in monocytes
11) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.21
Our work shows differential regulation of CD36 expression by TNF?
Regulation (regulation) of Gene_expression (expression) of CD36
12) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.71 Pain Relevance 0.37
We suggest that the F(ab')2 effect on CD36 expression may partially be the consequence of binding of this fragment of adalimumab to transmembrane TNF?.
Regulation (effect) of Gene_expression (expression) of CD36 associated with adalimumab
13) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.22
Mechanisms involved in the regulation of CD36 expression by TNF?
Regulation (regulation) of Gene_expression (expression) of CD36
14) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.27
These results suggest that ROS production is not involved in the repression of CD36 induced by TNF?.
Neg (not) Regulation (involved) of Gene_expression (repression) of CD36 associated with repression
15) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.24 Pain Relevance 0.22
Quantification of membrane expression of CD36 using flow cytometry
Regulation (Quantification) of Gene_expression (expression) of CD36
16) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.20
The combination of adalimumab and GW9662 did not inhibit the effect of adalimumab on CD36 membrane expression, which remained increased (205.5 ± 24.3 versus 122.8 ± 23.2, +67%, p = 0.003).
Regulation (effect) of Gene_expression (expression) of CD36 associated with adalimumab
17) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.45
, could account for the differential regulation of CD36 expression by TNF?
Regulation (regulation) of Gene_expression (expression) of CD36
18) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.55 Pain Relevance 0.42
Differential regulation of CD36 expression by TNF?
Regulation (regulation) of Gene_expression (expression) of CD36
19) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.61 Pain Relevance 0.43
The role of ROS production in the regulation of CD36 expression induced by TNF?
Regulation (regulation) of Gene_expression (expression) of CD36
20) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.09 Pain Relevance 0

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