INT209879

Context Info Confidence 0.10 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0.26

extracellular region (CSF2, TNFRSF11B) signal transduction (TNFRSF11B) extracellular space (CSF2) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency neutrophils 2 CSF2 (Homo sapiens) TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 12 98.68 rheumatoid arthritis 58 98.16 Inflammation 31 75.96 antagonist 1 64.16 Osteoarthritis 10 5.00 Arthritis 4 5.00 psoriasis 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 58 98.16 Apoptosis 8 84.88 Cancer 9 80.08 Necrosis 9 79.60 INFLAMMATION 30 75.96 Hypercalcemia 2 73.40 Immune System Diseases 1 46.24 Disease Progression 1 29.08 Osteoarthritis 10 5.00 Arthritis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, and GM-CSF cannot induce neutrophils to express the high concentrations of OPG observed with neutrophils from patients with RA, other factors are involved in inducing OPG.

GM-CSF Positive_regulation (induce) of Gene_expression (express) of OPG in neutrophils associated with rheumatoid arthritis

1) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.76 Pain Relevance 0.26

General Comments

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