INT209880

Context Info Confidence 0.09 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.74 Pain Relevance 0.23

extracellular region (IL4, TNFRSF11B) signal transduction (TNFRSF11B) extracellular space (IL4) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency neutrophils 2 IL4 (Homo sapiens) TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 58 98.00 cytokine 12 91.80 antagonist 1 75.68 Inflammation 31 69.08 Osteoarthritis 10 5.00 Arthritis 4 5.00 psoriasis 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 8 98.20 Rheumatoid Arthritis 58 98.00 Cancer 9 95.80 Necrosis 9 95.56 INFLAMMATION 30 69.08 Hypercalcemia 2 66.52 Immune System Diseases 1 39.36 Disease Progression 1 22.20 Osteoarthritis 10 5.00 Arthritis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effect of IL-4 on neutrophil expression of OPG, however, could be associated with the anti-apoptotic function of IL-4 through OPG inhibition of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) produced by human neutrophils [35,36].

IL-4 Regulation (effect) of Gene_expression (expression) of OPG in neutrophils associated with necrosis, cancer and apoptosis

1) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.74 Pain Relevance 0.23

General Comments

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