INT209885

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.41
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) intracellular (TNFSF11) cell-cell signaling (TNFRSF11A)
response to stress (TNFSF11) cytoplasm (TNFSF11) extracellular space (TNFSF11)
Anatomy Link Frequency
osteoclasts 1
TNFSF11 (Homo sapiens)
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 26 100.00 Very High Very High Very High
Inflammation 65 79.96 Quite High
rheumatoid arthritis 116 78.72 Quite High
psoriasis 2 30.68 Quite Low
Arthritis 8 28.36 Quite Low
Osteoarthritis 20 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 18 100.00 Very High Very High Very High
Cancer 18 100.00 Very High Very High Very High
Apoptosis 16 93.12 High High
Celiac Disease 128 89.80 High High
Death 4 88.40 High High
INFLAMMATION 63 79.96 Quite High
Rheumatoid Arthritis 116 78.72 Quite High
Wegener's Granulomatosis 4 78.44 Quite High
Diabetes Mellitus 78 70.08 Quite High
Osteoporosis 11 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RANK is activated by tumor necrosis factor-related activation-induced cytokine (TRANCE) [15].
TRANCE Positive_regulation (activated) of RANK associated with necrosis, cancer and cytokine
1) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.35 Pain Relevance 0.23
RANK is activated by tumor necrosis factor-related activation-induced cytokine (TRANCE) [15].
tumor necrosis factor-related activation-induced cytokine Positive_regulation (activated) of RANK associated with necrosis, cancer and cytokine
2) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.34 Pain Relevance 0.23
When the macrophage stimulating factor is present, RANKL activates its receptor RANK [117], leading to formation and activation of osteoclasts [118].
RANKL Positive_regulation (activates) of RANK in osteoclasts
3) Confidence 0.00 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2905696 Disease Relevance 0.71 Pain Relevance 0.09

General Comments

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