INT209886

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRAF6) signal transduction (TRAF6) nucleolus (TRAF6)
plasma membrane (TRAF6) nucleus (TRAF6) ligase activity (TRAF6)
Anatomy Link Frequency
dendritic cells 1
TRAF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 88.56 High High
rheumatoid arthritis 58 87.32 High High
cytokine 15 85.52 High High
psoriasis 1 39.28 Quite Low
Arthritis 4 36.96 Quite Low
Osteoarthritis 27 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 13 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Death 2 97.00 Very High Very High Very High
Apoptosis 8 96.56 Very High Very High Very High
INFLAMMATION 36 88.56 High High
Rheumatoid Arthritis 58 87.32 High High
Wegener's Granulomatosis 2 87.04 High High
Hypercalcemia 2 46.64 Quite Low
Osteoporosis 3 43.92 Quite Low
Psoriasis 1 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
upregulation of some genes, such as TNFR-1 and TNFR-2, TRAF-6 and IGFBP-6, whose transcription is under the control of NF-?
Positive_regulation (upregulation) of TRAF-6
1) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
During the immune response, mature dendritic cells express receptor activator of nuclear factor-kappa-B (RANK) and tumor necrosis factor receptor-associated factor 6 (TRAF6) [15,16].
Positive_regulation (activator) of TRAF6 in dendritic cells associated with necrosis and cancer
2) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.27 Pain Relevance 0.28

General Comments

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