INT209889

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 6.85
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRAF6) signal transduction (TRAF6) nucleolus (TRAF6)
plasma membrane (TRAF6) nucleus (TRAF6) ligase activity (TRAF6)
Anatomy Link Frequency
neutrophils 6
blood 1
dendritic cells 1
platelets 1
blood cells 1
TRAF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 809 99.98 Very High Very High Very High
Inflammation 464 99.64 Very High Very High Very High
Inflammatory marker 1 99.14 Very High Very High Very High
cytokine 215 85.52 High High
Arthritis 51 84.84 Quite High
tolerance 9 83.08 Quite High
antagonist 14 82.76 Quite High
Osteoarthritis 120 71.44 Quite High
psoriasis 16 50.96 Quite High
Inflammatory mediators 3 50.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 117 100.00 Very High Very High Very High
Necrosis 116 100.00 Very High Very High Very High
Rheumatoid Arthritis 809 99.98 Very High Very High Very High
INFLAMMATION 466 99.64 Very High Very High Very High
Death 25 97.68 Very High Very High Very High
Apoptosis 157 97.24 Very High Very High Very High
Wegener's Granulomatosis 24 87.72 High High
Arthritis 40 84.84 Quite High
Osteoarthritis 120 71.44 Quite High
Osteoporosis 36 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRAF6 expression by PBMLs was similar in CM and in SM with no significant changes from days 1 to 3 (data not shown).
Gene_expression (expression) of TRAF6
1) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0 Pain Relevance 0.03
The expression of TRAF6 by normal blood neutrophils, on the other hand, was detected in all the conditions tested but decreased significantly at day 3 in the presence of SM (Figure 3).
Gene_expression (expression) of TRAF6 in neutrophils
2) Confidence 0.55 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.10 Pain Relevance 0.06
During the immune response, mature dendritic cells express receptor activator of nuclear factor-kappa-B (RANK) and tumor necrosis factor receptor-associated factor 6 (TRAF6) [15,16].
Gene_expression (express) of TRAF6 in dendritic cells associated with necrosis and cancer
3) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.33 Pain Relevance 0.31
In contrast, freshly isolated peripheral blood neutrophils from healthy subjects expressed RANK-L and TRAF6, but not OPG and RANK (Figure 1a).
Neg (not) Gene_expression (expressed) of TRAF6 in blood
4) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.24 Pain Relevance 0.12
The expression of RANK-L, osteoprotegerin (OPG), RANK, and tumor necrosis factor receptor-associated factor 6 (TRAF6) was determined by polymerase chain reaction, enzyme-linked immunosorbent assay, Western blotting, and cytofluorometry.
Spec (determined) Gene_expression (expression) of TRAF6 associated with necrosis and cancer
5) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906801 Disease Relevance 0.78 Pain Relevance 0.33
To address this question, we investigated the expression of RANK-L, OPG, RANK, and TRAF6 mRNAs and proteins in neutrophils from the SF of patients with RA.
Spec (investigated) Gene_expression (expression) of TRAF6 in neutrophils associated with rheumatoid arthritis
6) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.69 Pain Relevance 0.29
The constant expression of TRAF6 by healthy and inflammatory neutrophils (Figures 1 and 3) suggests that this cytoplasmic adapter protein, which is required for immunity and bone homeostasis, is not a limiting factor in RANK-mediated neutrophil effector functions.
Gene_expression (expression) of TRAF6 in neutrophils associated with inflammation
7) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.50 Pain Relevance 0.18
Expression of RANK-L, OPG, RANK, and TRAF6 mRNAs by SF neutrophils from patients with RA and by healthy human blood cells
Gene_expression (Expression) of TRAF6 in blood cells associated with rheumatoid arthritis
8) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.19 Pain Relevance 0.09
The present report is the first to describe TRAF6 expression by neutrophils.
Gene_expression (expression) of TRAF6 in neutrophils
9) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.50 Pain Relevance 0.17
Freshly isolated neutrophils from SF of patients with RA expressed RANKL, OPG, TRAF6, and RANK as determined by semi-quantitative RT-PCR (Figure 1a).
Gene_expression (expressed) of TRAF6 in neutrophils associated with rheumatoid arthritis
10) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.20 Pain Relevance 0.10
PBMLs from healthy subjects expressed the four genes tested, and platelets expressed RANK-L, TRAF6, OPG, and not RANK (Figure 1b).
Gene_expression (expressed) of TRAF6 in platelets
11) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.30 Pain Relevance 0.15
Interestingly, TRAF6 is expressed by both inflammatory and healthy neutrophils and its expression is not modulated by any stimulus.
Gene_expression (expressed) of TRAF6 in neutrophils associated with inflammation
12) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.57 Pain Relevance 0.29
Interestingly, the expression of two targets of miR-146, TRAF6 and IL-1 receptor-associated kinase 1, remains unchanged although miR-146 is upregulated in PBMC from RA patients [22].
Gene_expression (expression) of TRAF6 associated with rheumatoid arthritis
13) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.80 Pain Relevance 0.12
The suppressed TRAF6 expression by miR-146a indicated that miR-146a may be a negative regulator in the TNF-?
Gene_expression (expression) of TRAF6
14) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.52 Pain Relevance 0.26
This effect is mediated through the TLR4-PI3K-AKT signaling pathway, as the induction of inflammatory markers was also inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6 or I?
Gene_expression (mutant) of TRAF6 associated with inflammatory marker
15) Confidence 0.22 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.15 Pain Relevance 0.18

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