INT209890

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 9.04
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD83) plasma membrane (CD83)
Anatomy Link Frequency
CD86 14
PDL-1 2
blood 2
monocytes 2
CD83 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 52 99.98 Very High Very High Very High
Inflammation 288 95.04 Very High Very High Very High
chemokine 62 94.08 High High
Multiple sclerosis 65 89.08 High High
Chronic pancreatitis 70 86.88 High High
rheumatoid arthritis 66 83.20 Quite High
psoriasis 1 69.68 Quite High
Arthritis 4 67.36 Quite High
pruritus 4 58.44 Quite High
antagonist 3 22.08 Low Low
Disease Link Frequency Relevance Heat
Adhesions 7 100.00 Very High Very High Very High
Adenocarcinoma 630 99.72 Very High Very High Very High
Hepatitis C Virus Infection 14 98.88 Very High Very High Very High
Breast Cancer 30 98.64 Very High Very High Very High
Phototoxic Dermatitis 48 97.88 Very High Very High Very High
INFLAMMATION 303 95.04 Very High Very High Very High
Apoptosis 35 91.60 High High
Multiple Sclerosis 69 89.08 High High
Photosensitivity Disorders 36 87.92 High High
Pancreatitis 70 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dose-dependent increases in CD86 and HLA-DR (but not CD83) expression were observed at radiation doses >1 J/cm2 UVA.
Positive_regulation (increases) of Gene_expression (expression) of CD83 in CD86
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.28 Pain Relevance 0
During these processes DCs undergo diverse phenotypical and functional changes such as reduced phagocytic ability, upregulated cell surface expression of co-stimulatory molecules and adhesion proteins, such as CD86, CD83, CD54, CD40, and MHC II antigens.
Positive_regulation (upregulated) of Gene_expression (expression) of CD83 in CD86 associated with adhesions
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.33 Pain Relevance 0.08
CPZ, a known photosensitizer with photoallergenic and phototoxic properties, was tested with and without irradiation and the induced modulation of CD86, CD83 and HLA-DR expressions as well as cell viability were measured by flow cytometry and compared 48 h after treatment.
Positive_regulation (induced) of Gene_expression (expressions) of CD83 in CD86
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0 Pain Relevance 0
The magnitude of that variability was investigated by measuring the expression of CD86, CD83 and HLA-DR on non-irradiated and irradiated, immature PBMDCs.
Spec (investigated) Positive_regulation (measuring) of Gene_expression (expression) of CD83 in CD86
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.12 Pain Relevance 0
CD83 expression was only elevated on PDCs (median 96).
Positive_regulation (elevated) of Gene_expression (expression) of CD83
5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.56 Pain Relevance 0.03
Of note, a partial mature blood DC phenotype, with elevated CD83 expression, correlated with the severity of breast cancer [22].
Positive_regulation (elevated) of Gene_expression (expression) of CD83 in blood associated with breast cancer
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.98 Pain Relevance 0.16
DCs maturation was evidenced by increased expression of CD83, CD80, CD86, HLA class I and II and CD40.
Positive_regulation (increased) of Gene_expression (expression) of CD83 in CD86
7) Confidence 0.29 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.13 Pain Relevance 0.04
We found a partial maturation of the blood MDCs and PDCs in PDAC patients with significantly enhanced expression of CD83, CD40, B7H3, PDL-1, CCR6, and CCR7 and decreased expression of ICOSL, and DCIR.
Positive_regulation (enhanced) of Gene_expression (expression) of CD83 in PDL-1 associated with adenocarcinoma
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 1.24 Pain Relevance 0.20
In addition, phlogogenic cytokines activate neutrophils to express CCR6, CD80, CD83, CD86, and CD40, an expression pattern that resembles a dendritic-like phenotype [10,11].
Positive_regulation (activate) of Gene_expression (express) of CD83 in CD86 associated with cytokine
9) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 1.16 Pain Relevance 0.55
PGE2 induced higher expression of CD83, CD86, and CCR7 on both MDCs and PDCs than accomplished by CXCL8 (Figure 11).
Positive_regulation (higher) of Gene_expression (expression) of CD83 in CD86
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.63 Pain Relevance 0.07
MDCs and PDCs from PDAC patients had increased levels of the maturation marker CD83 and the costimulatory molecule CD40
Positive_regulation (increased) of Gene_expression (levels) of CD83 associated with adenocarcinoma
11) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.77 Pain Relevance 0.10
CD40 and CD83 expression were significantly elevated both on MDCs and PDCs in patients with PDAC, but did not reach the level seen in fully mature cells.
Positive_regulation (elevated) of Gene_expression (expression) of CD83 associated with adenocarcinoma
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.07 Pain Relevance 0.17
Increased levels of CD40 and CD83 were observed on PDCs from HCV infected patients [13], whereas MDCs were less affected [13].
Positive_regulation (Increased) of Gene_expression (levels) of CD83 associated with hepatitis c virus infection
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.16 Pain Relevance 0.18
Control sample 8921A had a 26-fold increase in CD83 expression relative to the next highest control sample, and control sample 9018 had a 255-fold increase in SERPINB9 expression and a 156-fold increase in CD9 expression relative to the next highest samples for those genes (data not shown).
Positive_regulation (increase) of Gene_expression (expression) of CD83
14) Confidence 0.25 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.42 Pain Relevance 0.21
Similar to leptin effect on monocytes,it may increase the survival of dendritic cells, and it may also increase the expression of surface molecules, such as CD1a, CD80, CD83, or CD86.
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of CD83 in monocytes
15) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.21 Pain Relevance 0.07

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