INT209891

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.40
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRAF6) signal transduction (TRAF6) nucleolus (TRAF6)
plasma membrane (TRAF6) nucleus (TRAF6) ligase activity (TRAF6)
Anatomy Link Frequency
neutrophils 2
TRAF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 44 100.00 Very High Very High Very High
rheumatoid arthritis 114 98.16 Very High Very High Very High
tolerance 1 83.08 Quite High
Osteoarthritis 10 24.20 Low Low
cytokine 24 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 43 100.00 Very High Very High Very High
Rheumatoid Arthritis 114 98.16 Very High Very High Very High
Death 7 86.80 High High
Apoptosis 32 75.80 Quite High
Autoimmune Disease 6 61.04 Quite High
Disease 11 60.00 Quite High
Repression 3 42.56 Quite Low
Disease Progression 1 26.32 Quite Low
Osteoarthritis 10 24.20 Low Low
Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, TRAF6 is expressed by both inflammatory and healthy neutrophils and its expression is not modulated by any stimulus.
Neg (not) Regulation (modulated) of Gene_expression (expressed) of TRAF6 in neutrophils associated with inflammation
1) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.58 Pain Relevance 0.29
Interestingly, the expression of two targets of miR-146, TRAF6 and IL-1 receptor-associated kinase 1, remains unchanged although miR-146 is upregulated in PBMC from RA patients [22].
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of TRAF6 associated with rheumatoid arthritis
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.82 Pain Relevance 0.12

General Comments

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