INT209892

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
neutrophil 2
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 5 55.24 Quite High
rheumatoid arthritis 58 50.00 Quite Low
antagonist 6 50.00 Quite Low
cytokine 13 47.84 Quite Low
Inflammation 33 40.48 Quite Low
Osteoarthritis 10 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 116 99.44 Very High Very High Very High
Hypercalcemia 16 81.04 Quite High
Fibromyalgia 6 72.32 Quite High
Rheumatoid Arthritis 58 50.00 Quite Low
INFLAMMATION 32 40.48 Quite Low
Apoptosis 11 23.00 Low Low
Cancer 18 5.00 Very Low Very Low Very Low
Osteoarthritis 10 5.00 Very Low Very Low Very Low
Necrosis 9 5.00 Very Low Very Low Very Low
Osteoporosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of healthy blood neutrophils in CM or SM conditions for up to 3 days did not modify the membrane expression of RANK-L as evaluated by cytofluorometry and did not stimulate the release of detectable amounts of OPG in neutrophil supernatants as measured by EIA (data not shown).
Neg (not) Regulation (modify) of Gene_expression (expression) of RANK in neutrophil
1) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0 Pain Relevance 0
As M-CSF/RANKL-induced osteoclastogenesis was strongly inhibited in the presence of RSV analogues, we tested their effect on the expression of RANK, which is obligatory for inducing OC differentiation, and compared it to the expression of broader myeloid markers.
Regulation (effect) of Gene_expression (expression) of RANK associated with respiratory syncytial virus
2) Confidence 0.12 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.61 Pain Relevance 0.03

General Comments

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