INT209901

Context Info Confidence 0.38 First Reported 2007 Last Reported 2007 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.78 Pain Relevance 0.39

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency neutrophil 4 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 116 98.76 Inflammation 62 48.24 cytokine 24 47.20 Osteoarthritis 20 5.00 Arthritis 8 5.00 psoriasis 2 5.00 cINOD 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 116 98.76 INFLAMMATION 60 48.24 Apoptosis 16 25.52 Osteoarthritis 20 5.00 Necrosis 18 5.00 Cancer 18 5.00 Arthritis 6 5.00 Osteoporosis 6 5.00 Hypercalcemia 4 5.00 Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, the same SF neutrophils obtained from patients with RA and incubated for up to 4 days in CM showed a time-dependent release and accumulation of OPG in supernatants (Figure 2c).

Positive_regulation (accumulation) of Localization (release) of OPG in neutrophils associated with rheumatoid arthritis

1) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.72 Pain Relevance 0.36

Incubation of healthy blood neutrophils in CM or SM conditions for up to 3 days did not modify the membrane expression of RANK-L as evaluated by cytofluorometry and did not stimulate the release of detectable amounts of OPG in neutrophil supernatants as measured by EIA (data not shown).

Neg (not) Positive_regulation (stimulate) of Localization (release) of OPG in neutrophil

2) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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