INT209904

Context Info Confidence 0.40 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.13 Pain Relevance 0.10

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency neutrophils 2 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 58 69.36 Inflammation 35 60.96 cytokine 16 59.92 Osteoarthritis 76 50.00 Arthritis 5 5.00 cINOD 2 5.00 Pain 2 5.00 Bioavailability 1 5.00 Paracetamol 1 5.00 psoriasis 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 58 69.36 INFLAMMATION 35 60.96 Osteoarthritis 76 50.00 Osteoporosis 19 34.04 Apoptosis 9 12.40 Necrosis 10 5.00 Cancer 10 5.00 Hypercalcemia 9 5.00 Disease 8 5.00 Arthritis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The significantly increased levels of OPG with CS and GS incubated together appeared to result from the effect of the CS.

Positive_regulation (result) of Positive_regulation (increased) of OPG

1) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0 Pain Relevance 0

Prolongation of the incubation time up to 5 days in SM, however, led to an accumulation of OPG in the supernatants of these neutrophils (2.0 ± 0.4 pg/ml, n = 7).

Positive_regulation (led) of Positive_regulation (accumulation) of OPG in neutrophils

2) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.13 Pain Relevance 0.10

General Comments

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