INT20991

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.46
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
neutrophils 6
macrophages 1
blood 1
monocytes 1
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 7 100.00 Very High Very High Very High
lidocaine 5 99.64 Very High Very High Very High
Inflammation 143 99.08 Very High Very High Very High
cocaine 8 98.38 Very High Very High Very High
Enkephalin 6 97.28 Very High Very High Very High
Potency 4 95.08 Very High Very High Very High
local anesthetic 10 94.80 High High
anesthesia 1 87.92 High High
Nicotine 106 74.40 Quite High
metalloproteinase 20 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 220 100.00 Very High Very High Very High
Nicotine Addiction 425 99.66 Very High Very High Very High
INFLAMMATION 168 99.08 Very High Very High Very High
Urological Neuroanatomy 22 89.36 High High
Airway Obstruction 6 82.48 Quite High
Multiple Organ Failure 8 80.00 Quite High
Respiratory Distress 1 79.64 Quite High
Stress 3 73.60 Quite High
Chronic Obstructive Pulmonary Disease 49 68.08 Quite High
Critical Illness 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The up-regulation of CD11b induced by platelet-activating factor (PAF) priming was also inhibited by ropivacaine. fMLP increased adhesion of neutrophils to HUVECs, which was inhibited by ropivacaine.
Regulation (regulation) of CD11b in neutrophils associated with adhesions
1) Confidence 0.45 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.40 Pain Relevance 0.35
To assess the effect of opioid peptides on CD11a, CD11b, CD18 and CD16 molecule expression the whole blood samples were incubated with different concentrations of the opioids, then the white cells were labelled with respective PE-conjugated MoAb and evaluated by flow cytometry.
Regulation (effect) of CD11b in blood associated with opioid
2) Confidence 0.36 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0.15 Pain Relevance 0.91
The aim of this study was to investigate anti-inflammatory properties of ropivacaine with regard to its effects on the expression and function of CD11b in human neutrophils.
Regulation (effects) of CD11b in neutrophils associated with inflammation
3) Confidence 0.27 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.35 Pain Relevance 0.37
Cocaine and its derivatives blunted responses of neutrophils (cell/cell aggregation, up-regulation of the receptor for C3bi (CR3, CD11b/CD18), generation of superoxide anion (O2-) and degranulation to various stimuli.
Regulation (regulation) of CD11b in neutrophils associated with cocaine
4) Confidence 0.26 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2161879 Disease Relevance 0 Pain Relevance 0.50
We found that tobacco smoking did not acutely influence CD11b expression levels on primary neutrophils.
Neg (not) Regulation (influence) of CD11b in neutrophils associated with nicotine addiction
5) Confidence 0.16 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 1.00 Pain Relevance 0.13
Thus, up-regulation of CD11b/CD18 in primed neutrophils, coupled with endothelial ICAM-1 expression, would be expected to contribute to inappropriate neutrophil adhesion in smokers in cardiovascular, pulmonary, or other environments, with potential ramifications to local tissue integrity.
Regulation (regulation) of CD11b in neutrophils associated with nicotine addiction and adhesions
6) Confidence 0.10 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.99 Pain Relevance 0
Thus, up-regulation of CD11b/CD18 in primed neutrophils, coupled with endothelial ICAM-1 expression, would be expected to contribute to inappropriate neutrophil adhesion in smokers in cardiovascular, pulmonary, or other environments, with potential ramifications to local tissue integrity.
Regulation (regulation) of CD11b in neutrophils associated with nicotine addiction and adhesions
7) Confidence 0.10 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.99 Pain Relevance 0
To our knowledge the effect of

CVVHD on the important adhesion molecules CD11a, CD11b, CD18 and CD44 has not been investigated before.

Spec (investigated) Regulation (effect) of CD11b associated with adhesions
8) Confidence 0.07 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.07 Pain Relevance 0
Figure 3 shows the effect of 0.5 and 2 mg pretreatments with FP on O3-induced changes in the cell-surface markers CD11b, mCD14, CD64, CD16, HLA-DR, and CD86 on monocytes, macrophages, and DCs.
Regulation (effect) of CD11b in macrophages
9) Confidence 0.05 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.25 Pain Relevance 0
Figure 3 shows the effect of 0.5 and 2 mg pretreatments with FP on O3-induced changes in the cell-surface markers CD11b, mCD14, CD64, CD16, HLA-DR, and CD86 on monocytes, macrophages, and DCs.
Regulation (effect) of CD11b in monocytes
10) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.25 Pain Relevance 0

General Comments

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