INT209911

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pycard) extracellular region (Pycard) intracellular (Pycard)
protein complex (Pycard) cytoplasm (Pycard)
Anatomy Link Frequency
posterior 1
Pycard (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 90.08 High High
Inflammation 16 74.16 Quite High
cytokine 4 71.48 Quite High
corticosteroid 4 58.76 Quite High
cINOD 11 57.44 Quite High
Calcitonin gene-related peptide 3 54.56 Quite High
anakinra 24 50.00 Quite Low
Arthritis 23 48.48 Quite Low
Pain 7 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cataract 68 100.00 Very High Very High Very High
INFLAMMATION 24 89.76 High High
Targeted Disruption 16 86.60 High High
Crystal Associated Disease 76 85.52 High High
Gastrointestinal Disease 1 65.56 Quite High
Syndrome 3 49.52 Quite Low
Apoptosis 7 48.68 Quite Low
Arthritis 19 48.48 Quite Low
Ocular Hypertension 1 46.64 Quite Low
Hyperplasia 3 30.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
into the rat eye [32] has been shown to produce ASC following 15 weeks post injection, however the ASC were not well defined and were accompanied by a number of other lens defects, including cortical clouding, disrupted bow region, nucleated fiber cells, vacuolation of fiber cells, and posterior subcapsular cataracts containing swollen and degenerating cells.
Neg (not) Protein_catabolism (well) of ASC in posterior associated with cataract
1) Confidence 0.11 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2647562 Disease Relevance 0.86 Pain Relevance 0.05
On assembly of the inflammasome, which consists of a member of the nucleotide-binding oligomerization domain-leucine rich repeat protein family (such as NALP1, NALP2, NALP3, or IPAF), the adaptor protein ASC and caspase-1 [7], caspase-1 becomes active and cleaves pro-IL-1?
Protein_catabolism (cleaves) of ASC
2) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.73 Pain Relevance 0.27

General Comments

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